Heather A. Wakelee, MD

Heather A. Wakelee, MD, professor of medicine at Stanford University, discusses recent research investigating antiangiogenic agents and checkpoint inhibitors in the frontline for patients with

-positive nonsmall cell lung cancer (NSCLC). The most promising data were demonstrated in the phase III IMpower150 trial (NCT02366143).

Patients enrolled to the IMpower150 trial were treated with a 4-drug combination, including atezolizumab (Tecentriq), bevacizumab (Avastin), carboplatin, and paclitaxel. Patients with

-positive NSCLC experienced an improvement in overall survival (OS) and progression-free survival (PFS) with the 4-drug regimen.

Other clinical trials investigated these agents in patients with advanced NSCLC, such as ECOG-ACRIN 5508 (NCT01107626)looking at maintenance bevacizumab alone versus in combination with pemetrexed or pemetrexed alone and the COMPASS trial (NCT01776424)investigating bevacizumab with or without pemetrexed after induction with carboplatin, pemetrexed, and bevacizumab. Both studies showed an improvement in PFS but not OS. However, these were exciting trial designs, Wakelee notes.

The IMpower150 trial was the first trial to combine antiangiogenic agents with immunotherapy; Wakelee says she is excited to see the checkpoint inhibitors being used in this space. PFS and OS were improved in all comers on the trial, including those with

Videos

Heather A. Wakelee, MD, discusses recent research investigating antiangiogenic agents and checkpoint inhibitors in the frontline for patients with <em>EGFR</em>-positive non&mdash;small cell lung cancer. The most promising data were demonstrated in the phase III IMpower150 trial.

Research Investigates Role of Antiangiogenic Agents and Checkpoint Inhibitors in EGFR NSCLC

Heather A. Wakelee, MD, an associate professor at Stanford University School of Medicine, discusses the use of osimertinib (Tagrisso) as a frontline treatment option for patients with

In this patient population, there are several first- and second-generation options, according to Wakelee. Third-generation osimertinib was approved by the FDA for this population, as well, with supportive data directly comparing different tyrosine kinase inhibitors in the frontline.

Heather A. Wakelee, MD, discusses the use of osimertinib as a frontline treatment option for patients with <em>EGFR</em>-positive lung cancer.

Examining Data for Osimertinib in EGFR+ Lung Cancer

Heather A. Wakelee, MD, associate professor of Medicine (Oncology), Stanford University Medical Center, discusses a study utilizing liquid biopsies in patients with nonsmall cell lung cancer who harbor

Heather A. Wakelee, MD, discusses a study utilizing liquid biopsies in patients with non-small cell lung cancer who harbor EGFR mutations. 

Heather A. Wakelee, MD | Authors

Articles

Research Investigates Role of Antiangiogenic Agents and Checkpoint Inhibitors in EGFR NSCLC

Examining Data for Osimertinib in EGFR+ Lung Cancer

Use of Liquid Biopsies for Patients With EGFR-Mutated NSCLC