August 2018

Targeting EZH2 Delivers Promising Activity in Lymphomas

August 17, 2018

Clinical Articles

Targeting EZH2, the catalytic subunit of the multiprotein PRC2, may represent an attractive therapeutic objective in malignant lymphoma, Vincent Ribrag, MD, told his audience at the American Association for Cancer Research’s inaugural Advances in Malignant Lymphoma meeting.

Pathway-Dependent Strategies Using Novel Combinations May Represent a New Plan of Attack in Treating T-Cell Lymphomas

August 17, 2018

Clinical Articles

During a presentation at the American Association for Cancer Research’s inaugural Advances in Malignant Lymphoma meeting, Mehta-Shah, associate professor in the Department of Medicine with Washington University School of Medicine in St. Louis, presented preliminary data showing how new pathway-dependent strategies using novel agent combinations may represent a new way to treat patients with T-cell lymphomas.

Immunotherapy Combinations Are Changing the Frontline Treatment of Patients With NSCLC

August 16, 2018

Clinical Articles

Checkpoint inhibitors are revolutionizing the treatment of patients with both squamous and nonsquamous non-small cell lung cancer, and are quickly assuming a predominant role, especially in the frontline setting, due to recent exciting results from large trials.

Early Signs of Efficacy Seen With Mesothelin CAR T-Cell Therapy

August 17, 2018

Clinical Articles

Mesothelin-targeted chimeric antigen receptor T-cell therapy has shown early evidence of efficacy in a phase I trial of patients with malignant pleural disease and mesothelioma, non–small cell lung cancer, or breast cancer. Additionally, significant responses were seen in patients who went on to receive subsequent PD-1 checkpoint inhibition treatment.

Biomarker Development Is Key to the Future of Precision Oncology

August 21, 2018

Clinical Articles

No one doubts that molecular testing has rapidly improved care for patients with colorectal cancer, Stanley R. Hamilton, MD, told his audience at the 2nd Annual International Congress on Oncology Pathology.

Sidney Kimmel Cancer Center Tackles OCM Transformation With Data Visualization Tool

August 20, 2018

Clinical Articles

Although the Oncology Care Model has policy goals of improving care quality and reducing costs, data operationalization has proven to be more complex and confusing than anticipated since its debut in 2015 from the Centers for Medicare & Medicaid Services. Despite these challenges, many OCM-participating practices have been successful and reap the benefit of value-based care.