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Opinion|Videos|January 16, 2025

Alternative Clinical Approaches and Data for Patients not Suitable for 2L CAR T

Author(s)Aimee Merino, MD

Panelists discuss treatment options for patients ineligible for chimeric antigen receptor T-cell therapy in the second-line setting, focusing on the selection of new proteasome inhibitors and/or immune-mediated immunomodulatory drugs vs recycling combination regimens, and reviewing recent data from the APOLLO and IKEMA trials that support the use of combination therapies in relapsed/refractory multiple myeloma.

Episodes in this series

EP. 1 A 60-Year-Old Man With Early Relapse Multiple Myeloma

EP. 1 A 60-Year-Old Man With Early Relapse Multiple Myeloma

EP. 2 Identification, Evaluation, and Management of High-Risk Disease in Early R/R MM

EP. 2 Identification, Evaluation, and Management of High-Risk Disease in Early R/R MM

EP. 3 Overview of Referral of CAR T for Early R/R Multiple Myeloma

EP. 3 Overview of Referral of CAR T for Early R/R Multiple Myeloma

EP. 4 CARTITUDE-4: Latest Data of Cilta-Cel for Early R/R MM

EP. 4 CARTITUDE-4: Latest Data of Cilta-Cel for Early R/R MM

EP. 5 Navigating Early versus Late Toxicities with CAR T in Myeloma

EP. 5 Navigating Early versus Late Toxicities with CAR T in Myeloma

EP. 6 Alternative Clinical Approaches and Data for Patients not Suitable for 2L CAR T

EP. 6 Alternative Clinical Approaches and Data for Patients not Suitable for 2L CAR T

EP. 7 Future Implications for CAR T in Early RRMM and Treatment Sequencing

EP. 7 Future Implications for CAR T in Early RRMM and Treatment Sequencing

Video content above is prompted by the following:

For patients not suitable to receive chimeric antigen receptor T-cell therapy in the second line, what current/emerging treatments would you consider?
How do you approach selecting a new proteasome inhibitor and/or immune-mediated immunomodulatory drug vs recycling a combination regimen?
Briefly comment on recent data in combination regimens that support their use:
APOLLO trial, DPd vs Pd in patients with relapsed/refractory multiple myeloma (R/R MM)
IKEMA trial, Isa-Kd vs Kd in patients with R/R MM

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