Dr. Anthony Mato on the Difference Between Intolerance and Resistance in CLL

Anthony Mato, MD, MSCE, director of the CLL Program, University of Pennsylvania, discusses the difference between intolerance and resistance when giving patients with chronic lymphotic leukemia ibrutinib.

Anthony Mato, MD, MSCE, director of the Chronic Lymphotic Leukemia (CLL) Program, University of Pennsylvania, discusses the difference between intolerance and resistance when giving patients with CLL ibrutinib. Mato says when it comes to resistance, medical professionals should be wary of certain mutations occurring that disallow ibrutinib to bind to targets such as BTK. Mato adds that patients showing resistance to idelalisib is unclear is currently under investigation as to reasons why.

Mato adds that there is no clinical model to predict resistance at this juncture. He says the concept of resistance is too complex to be able to predict.