Areas Under Investigation in Ph-Like ALL

Sarah K. Tasian, MD, attending physician and assistant professor of pediatrics in the Division of Oncology at Children’s Hospital of Philadelphia, discusses what she finds most interesting about Philadelphia chromosome (Ph-like) acute lymphoblastic leukemia (ALL).

Tasian is surprised by how heterogenous the disease is and how they are always discovering new fusions. Despite the number of lesions, she says patients have either 1 of 2 pathways:BCR-ABLor CRLF2-R/JAK.