Commentary|Videos|March 13, 2026

Deescalation in Diffuse Large B-Cell Lymphoma

Fact checked by: Paige Britt

Real-time ctDNA MRD testing guides early chemo de-escalation in diffuse large B-cell lymphoma, aiming to cut toxicity without losing cure rates.

In an interview with Targeted Oncology, Hua-Jay “Jeff” Cherng, MD, assistant professor of medicine in the lymphoma program in the Division of Hematology and Oncology at the Columbia University Irving Medical Center, discussed the details of the SHORTEN-ctDNA trial (NCT06693830).¹ Dr Cherng explained how using real-time circulating tumor (ct)DNA monitoring can decide which patients with newly diagnosed diffuse large B-cell lymphoma can safely 'deescalate' their chemotherapy.

REFERENCE

1.ctDNA-guided therapy optimization in newly diagnosed DLBCL. ClinicalTrials.gov. Updated January 23, 2026. Accessed March 11, 2026. https://clinicaltrials.gov/study/NCT06693830

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Deescalation in Diffuse Large B-Cell Lymphoma

REFERENCE

1.ctDNA-guided therapy optimization in newly diagnosed DLBCL. ClinicalTrials.gov. Updated January 23, 2026. Accessed March 11, 2026. https://clinicaltrials.gov/study/NCT06693830

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