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Opinion|Videos|July 29, 2024

Dose Escalation of Luspatercept on Trial and Real-World Data

Author(s)Guillermo Garcia-Manero, MD

Guillermo Garcia-Manero, MD, addresses clinical research investigating luspatercept dose titration practices in patients with lower-risk MDS.

Episodes in this series

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 1 Overview of Lower-Risk Myelodysplastic Syndromes (LR-MDS)

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 2 Standard-of-Care Treatment for Patients with LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 3 Erythroid Maturating Agents (EMAs) for Frontline or Second-Line Treatment of Anemia in LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 4 COMMANDS Trial: Study Design, Patient Population, and Results

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 5 Classification Changes Impacting the Treatment of LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 6 Dose Escalation of Luspatercept on Trial and Real-World Data

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 7 Adverse Events with EMAs: Luspatercept

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 8 Current Approach for Treating Anemia in LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 9 Future Treatment for Anemia of LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 10 Clinical Pearls for Community Oncologist Treating LR-MDS

Video content above is prompted by the following:

Per the COMMANDS trial schema, luspatercept was initiated at 1.0 mg/kg with titration allowed at 2 levels to a maximum of 1.75 mg/kg.
- Please discuss the efficacy data associated with up titration and the number of participants who required dose escalation in the trial.
- At the 2024 EHA Congress, data was presented on real-world dose escalation of luspatercept and clinical outcomes. Please discuss the findings and the impact on TI for patients originally TD and for patients for patients NTD prior to dose escalation.

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