Investigating Combination Therapies in Mantle Cell Lymphoma

Brian T. Hill, MD, PhD

Brian T. Hill, MD, PhD, director of Lymphoid Malignancies at the Cleveland Clinic, discusses current combinations being investigated for the treatment of patients with mantle cell lymphoma.

Brian T. Hill, MD, PhD, director of Lymphoid Malignancies at the Cleveland Clinic, discusses current combinations being investigated for the treatment of patients with mantle cell lymphoma (MCL).

There is a lot of interest in the combination of BTK inhibitors with other agents, Hill says. For example, the combination of ibrutinib plus venetoclax is currently being tested in this patient population.

Other combinations being investigated include ixazomib (Ninlaro), an oral proteasome inhibitor, and ibrutinib. It is already known that proteasome inhibitors are active in MCL. Hill says results from this study will be interesting.