Luspatercept Lowers the Transfusion Burden in Patients With Myelofibrosis-Associated Anemia

February 19, 2020
Aaron Gerds, MD

Aaron Gerds, MD discusses the results of a phase II BELIEVE study of luspatercept as treatment of patients with myelofibrosis-associated anemia.

Aaron Gerds, MD, assistant professor of Medicine, Cleveland Clinic - Taussig Cancer Center, discussed the results of a phase II BELIEVE study of luspatercept (Reblozyl) as treatment of patients with myelofibrosis-associated anemia.

Every cohort in the study had responses to treatment with luspatercept. Additionally, luspatercept successfully reduced the transfusion burden in 21.4% of the study subjects compared only 4.5% of those who received placebo, meeting the primary end point of the study.

Gerd notes, however, that responses were higher in patients who received ruxolitinib (Jakafi) along with the luspatercept.

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