Immunotherapy Potential in Locally Advanced CSCC

A 69-Year-Old Man With Advanced CSCC

• History and physical exam
  • An otherwise healthy, 69-year-old male, fair skinned, retired construction worker, widow
  • Presented to his PCP with what he described as a wound that was not healing behind his ear; he reported first noticing it at least 6 months ago and complained of recent onset of numbness in the area.
  • ECOG PS 1
  • The visible, ulcerated lesion was 4.5-cm in diameter and >5-mm deep
  • No palpable nodes
• Biopsy confirmed a poorly-differentiated, infiltrative, postauricular cutaneous squamous cell carcinoma lesion with 7-mm invasion into subcutaneous fat.
• The recommended definitive surgical approach involved partial auriculectomy; the patient declined.
• Cemiplimab 3 mg/kg q2w was initiated