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Commentary|Videos|February 16, 2026

Narrowing the Scope: PARP Inhibitor Restrictions in Ovarian Cancer

Author(s)Erin Crane, MD, MPH

Fact checked by: Paige Britt

New data links PARP maintenance after recurrence to higher AML/MDS risk and shorter survival, pushing most use to frontline therapy.

The landscape of gynecologic oncology is rapidly shifting toward a precision-based approach, where treatment decisions are increasingly dictated by a tumor's molecular fingerprint. In 2026, the focus has moved beyond general chemotherapy toward personalized maintenance strategies that utilize biomarkers like homologous recombination deficiency and proficient mismatch repair to predict patient response.

In an interview with Targeted Oncology, Erin Crane, MD, MPH, discusses PARP inhibitor restrictions in gynecologic oncology.

Watch part 1 of the interview here.

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