Publication|Articles|December 23, 2024

December I, 2024
Pages: 72

Roundtable Roundup: Choosing a Bispecific Antibody for R/R Multiple Myeloma

In separate, live events, Binod Dhakal, MD, MS; and Laahn H. Foster, MD, polled oncologists on therapeutic options for a patient with multiple myeloma and progressive disease.

CASE SUMMARY

A 72-year-old man was diagnosed 6 years ago with multiple myeloma, with 60% plasma cells and translocation 14;20.
Medical history: respiratory infections (2 episodes of pneumonia and multiple episodes of bronchitis over prior 10 years)
He received 5 prior lines of therapy, most recently chimeric antigen receptor T-cell infusion
He now presents with progressive disease (elevated free light chain, creatinine level of 2.3 mg/dL)
ECOG performance status: 2

CASE UPDATE

Talquetamab is initiated via step-up dosing (SUD) up to 800 μg/kg every 2 weeks (Q2W).

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