The Difference Between Blocking PD-1 and PD-L1 in Melanoma

Clinical Pearls

Harriet Kluger, MD, associate professor of medicine (medical oncology), associate director, Hematology/Oncology Fellowship Program, Yale Cancer Center, discusses the difference between blocking PD-1 and PD-L1 in melanoma.

• The complete biology of PD-L1 is not known yet, though there is a theory that blocking it will be less toxic than blocking PD-1
• The toxicity and activity is different in PD-1 and PD-L1