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Opinion|Videos|August 12, 2024

The Expanding Treatment Armamentarium and Clinical Decision Making: ExteNET, DestinyBREAST-05, HER2CLIMB, and Other Emerging Trials

Author(s)Paolo Tarantino, MD

Dr. Tarantino discuss the integration of recent trial data into post-neoadjuvant treatment strategies, comparing adjuvant T-DM1 with pertuzumab plus trastuzumab.

Episodes in this series

Rebecca A. Shatsky, MD, an expert on breast cancer

EP. 1 Overview of HER2-Targeting Agents in Breast Cancer and Treatment Selection Approaches

Video 3 - "APHINITY Trial: Pertuzumab for Patients with HER2+ Breast Cancer"

EP. 2 APHINITY Trial: Pertuzumab for Patients with HER2+ Breast Cancer

Video 4 - "KATHERINE: Adjuvant T-DM1 vs Trastuzumab for Residual Invasive HER2+ Breast Cancer"

EP. 3 KATHERINE: Adjuvant T-DM1 vs Trastuzumab for Residual Invasive HER2+ Breast Cancer

Video 5 - "Exciting Developments in HER2+ Breast Cancer"

EP. 4 Exciting Developments in HER2+ Breast Cancer

Video 6 - "Current Approaches to Treatment Sequencing in HER2+ Breast Cancer"

EP. 5 Current Approaches to Treatment Sequencing in HER2+ Breast Cancer

Video 7 - "Unmet Needs and Future Directions in HER2+ Breast Cancer"

EP. 6 Unmet Needs and Future Directions in HER2+ Breast Cancer

Rebecca A. Shatsky, MD, an expert on breast cancer

EP. 7 Risk Stratification and Treatment Selection in HER2+ Breast Cancer: The Current Treatment Landscape and NCCN Guideline Recommendations

Rebecca A. Shatsky, MD, an expert on breast cancer

EP. 8 Long-Term Pertuzumab Outcomes in HER2+ Breast Cancer: Insights from APHINITY 8-Year Data and NeoSphere Pooled Analysis

Rebecca A. Shatsky, MD, an expert on breast cancer

EP. 9 KATHERINE Trial: Long-Term Outcomes of T-DM1 vs Trastuzumab in HER2+ Breast Cancer with Residual Disease

Rebecca A. Shatsky, MD, an expert on breast cancer

EP. 10 The Expanding Treatment Armamentarium and Clinical Decision Making: ExteNET, DestinyBREAST-05, HER2CLIMB, and Other Emerging Trials

Rebecca A. Shatsky, MD, an expert on breast cancer

EP. 11 Unmet Needs and Future Directions in HER2+ Breast Cancer Management

Video content above is prompted by the following:

How might these data factor into your treatment considerations post neoadjuvant treatment?
- When would you recommend adjuvant T-DM1 over adjuvant pertuzumab plus trastuzumab in this setting?
With a growing number HER2-targeting agents available, how do you approach the decision-making process in your practice? Please comment on other trials investigating HER2 targeting agents?
- Trastuzumab
- Tucatinib
- Neratinib
  - How do you evaluate and compare data from clinical trials for these agents?
What are the factors you consider when selecting between HER2-targeted agents?
What are your considerations for optimal sequencing of these therapies?

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