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Opinion|Videos|August 21, 2024

The Role of Luspatercept as First-Line Treatment in Lower-Risk MDS

Medical experts examine the role of luspatercept as a first-line treatment for anemia in lower-risk MDS patients, including those with RS+/RS- and serum EPO ≤200 mU/L, and discuss its efficacy and potential benefits for this population.

Episodes in this series

EP. 1 Overview of Low-Risk MDS: Clinical Hallmarks and Current Treatments

EP. 1 Overview of Low-Risk MDS: Clinical Hallmarks and Current Treatments

EP. 2 Incorporating Prognostic Scoring Systems in Treatment Decisions for Lower-Risk MDS

EP. 2 Incorporating Prognostic Scoring Systems in Treatment Decisions for Lower-Risk MDS

EP. 3 The Role of Luspatercept as First-Line Treatment in Lower-Risk MDS

EP. 3 The Role of Luspatercept as First-Line Treatment in Lower-Risk MDS

EP. 4 Impact of Improved Hemoglobin Levels on Patient Well-being and Quality of Life

EP. 4 Impact of Improved Hemoglobin Levels on Patient Well-being and Quality of Life

EP. 5 Approaches to Initiating and Adjusting Luspatercept Dosing

EP. 5 Approaches to Initiating and Adjusting Luspatercept Dosing

EP. 6 Comparing Treatment Options: Luspatercept vs. Erythropoiesis-Stimulating Agents (ESAs)

EP. 6 Comparing Treatment Options: Luspatercept vs. Erythropoiesis-Stimulating Agents (ESAs)

Solly Chedid, MD, and Jamie Koprivnikar, MD

EP. 7 Advancing the Treatment Landscape for Lower-Risk MDS: Unmet Needs and Future Directions

Solly Chedid, MD, and Jamie Koprivnikar, MD

EP. 8 Transitioning to Alternative Therapies: Topoisomerase Inhibitors vs. Hypomethylating Agents

Video content above is prompted by the following question(s):

Luspatercept has been available to treat anemia in LR MDS after failing an ESA since 2020. Later in 2023, it was approved as first-line treatment for anemia in LR MDS for patients who may require transfusions.

Please discuss the role of luspatercept in the 1L treatment of lower-risk MDS patients, particularly those RS+/RS-; serum EPO ≤200 mU/L

What are your thoughts on the efficacy and potential benefits of luspatercept in this patient population?

Please discuss the how mutational burden impacts response and duration of response in the COMMANDS trial.

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