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Opinion|Videos|August 28, 2024

Comparing Treatment Options: Luspatercept vs. Erythropoiesis-Stimulating Agents (ESAs)

Experts discuss factors influencing the choice between luspatercept and erythropoiesis-stimulating agents (ESAs) for initial anemia treatment, considerations for transitioning patients from ESAs to luspatercept, optimal timing for such transitions, and the clinical benefits of luspatercept dose titration as evidenced by real-world data presented at EHA 2024.

Episodes in this series

EP. 1 Overview of Low-Risk MDS: Clinical Hallmarks and Current Treatments

EP. 1 Overview of Low-Risk MDS: Clinical Hallmarks and Current Treatments

EP. 2 Incorporating Prognostic Scoring Systems in Treatment Decisions for Lower-Risk MDS

EP. 2 Incorporating Prognostic Scoring Systems in Treatment Decisions for Lower-Risk MDS

EP. 3 The Role of Luspatercept as First-Line Treatment in Lower-Risk MDS

EP. 3 The Role of Luspatercept as First-Line Treatment in Lower-Risk MDS

EP. 4 Impact of Improved Hemoglobin Levels on Patient Well-being and Quality of Life

EP. 4 Impact of Improved Hemoglobin Levels on Patient Well-being and Quality of Life

EP. 5 Approaches to Initiating and Adjusting Luspatercept Dosing

EP. 5 Approaches to Initiating and Adjusting Luspatercept Dosing

EP. 6 Comparing Treatment Options: Luspatercept vs. Erythropoiesis-Stimulating Agents (ESAs)

EP. 6 Comparing Treatment Options: Luspatercept vs. Erythropoiesis-Stimulating Agents (ESAs)

Solly Chedid, MD, and Jamie Koprivnikar, MD

EP. 7 Advancing the Treatment Landscape for Lower-Risk MDS: Unmet Needs and Future Directions

Solly Chedid, MD, and Jamie Koprivnikar, MD

EP. 8 Transitioning to Alternative Therapies: Topoisomerase Inhibitors vs. Hypomethylating Agents

Video content above is prompted by the following question(s):

When it comes to initial anemia treatment beyond transfusions, there are different options available including luspatercept and erythropoiesis-stimulating agents (ESAs).
- What factors would you consider when deciding between these therapies for a particular patient?
For patients already on ESAs, what would prompt you to consider transitioning them to luspatercept therapy?
How do you determine the appropriate timing for such a switch?
Please discuss the clinical benefit of luspatercept dose titration from the RWE data presented at EHA 2024.

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