Toxicities Associated With CAR-Modified T Cell Therapy

Clinical Pearls

Jae Park, MD, assistant attending physician, Memorial Sloan Kettering Cancer Center, discusses toxicities associated with CAR-modified T cell therapy.

• There are unique toxicities associated with CAR-modified T cell therapy, such as cytokine release syndrome.
• Cytokine release syndrome can cause a patient to experience fever, low blood pressure, and breathing problems.
• There are now ways for a physician to predict the occurrence and severity of cytokine release syndrome.
• IL-6 receptor inhibitors or steroids can effectively manage cytokine release syndrome.