Jonah Feldman is an assistant editor for Targeted Oncology and Peers and Perspectives in Oncology.
Ruxolitinib for GVHD in Patients < 2 Years Old Shows Variable Pharmacokinetics
February 17th 2023According to findings presented at the 2023 Transplantation & Cellular Therapy Meetings, experts did not identify clear correlation between the pharmacokinetics and pharmacodynamics of ruxolitinib in patients with graft-vs-host-disease.
Preliminary VITALIZE Results Show CRs to IO Combination in R/R DLBCL
February 15th 2023Early results announced from the VITALIZE study show efficacy and safety of maveropepimut-S plus pembrolizumab and low-dose, intermittent cyclophosphamide for patients with relapsed/refractory diffuse large B-cell lymphoma.
Brexu-Cel Shows Comparable Outcomes With ZUMA-2 in Real-World MCL
February 14th 2023Patients treated with brexucabtagene autoleucel as standard of care in US Lymphoma CAR T Consortium centers responded to treatment consistently with the ZUMA-2 trial, showing real-world efficacy and safety as well as additional data on outcomes for patients with high-risk features and different bridging therapies.
Continuing CDK4/6 Does Not Improve PFS in ER+/HER2- Breast Cancer
December 8th 2022The combination of palbociclib and fulvestrant beyond progression on prior CDK4/6 inhibitor did not show significant improvements in progression-free survival compared with fulvestrant alone in ER-positive/HER2-negative breast cancer.
Study of Ponatinib Versus Imatinib Meets Primary End Point in Ph+ ALL
November 30th 2022Takeda Pharmaceuticals announced that the phase 3 PhALLCON trial of ponatinib for Philadelphia-positive acute lymphoblastic leukemia succeeded in improving the rate of minimal residual disease–negative complete remission.
Case of Twins with Rare Stem Cell Disorder Wins Best Overall Abstract at Congress on MPNs
October 28th 2022At the 14th International Congress on Myeloproliferative Neoplasms, research into the case of dizygotic twins with essential thrombocythemia won the Best overall Abstract Award for concluding how their rare stem cell disorder was passed between both twins.