Case Based Peer Perspectives

Ian Flinn, MD, PhD, reviews the case of a 68-year-old man with two relapses of DLBCL, discusses the challenges of R/R DLBCL management and the potential treatment options, and highlights the critical needs of such patients.

Gilles Salles, MD, PhD, presents the case of a woman with relapsed/refractory DLBCL who refused stem cell transplant and CAR T-cell therapy, explains the available third-line treatment options, and discusses clinical trial data on a promising combination therapy.

Matthew Lunning, DO, FACP, presents the case of a man with diffuse large B-cell lymphoma and reviews the available treatment options, including options after relapse and chemorefractory disease.

Grzegorz S. Nowakowski, MD, reviews the case of a 76-year-old woman with DLBCL and discusses the available treatment options, including options after relapse.

Dr Catherine Coombs discusses considerations for treatment selection in the context of a patient case with relapsed/refractory chronic lymphocytic leukemia.

Raajit Rampal, MD, PhD, reviews the case of a 67-year-old man with primary myelofibrosis.

Expert perspectives on the diagnosis and management of uncontrolled polycythemia vera in a 60-year-old man.

Expert hematologist-oncologist Ajay Nooka, MD, MPH, FACP, centers discussion around a clinical case to review updates in the treatment of newly diagnosed multiple myeloma.

Expert hematologist-oncologist Rafael Fonseca, MD, reviews the diagnosis and management of an 81-year-old-man who presents with transplant-ineligible multiple myeloma.

Expert oncologist Zofia Piotrowska, MD, reviews the case of a 59-year-old woman who is diagnosed and treated for EGFR exon 20–positive non–small cell lung cancer.

Expert Joel Neal, MD, PhD, speaks to the management of a 64-year-old man diagnosed with EGFR exon20 insertion–positive NSCLC.

John Mascarenhas, MD, reviews the case of a 76-year-old woman with myelofibrosis and her treatment with pacritinib.

Srdan Verstovsek, MD, PhD, provides insight on treatment of primary myelofibrosis, including ruxolitinib, and comments on some of the challenges, unmet needs, and future directions in the field.

Dr John Allan reviews the case of a 70-year-old woman with newly diagnosed CLL and discusses current treatment strategies and challenges.

Pashna Munshi, MD, comments on available treatments for steroid-refractory chronic graft-versus-host disease (cGVHD), including ruxolitinib, and discusses challenges to diagnosis and management of the disease.

Yi-Bin Chen, MD, provides insight on treatment of steroid-refractory chronic GVHD with ruxolitinib.

Expert Leslie Randall, MD, discusses the case of a 71-year-old woman who is diagnosed with ovarian cancer. Dr. Randall reviews data with PARP inhibitors and rationale for use of maintenance therapy in patients with platinum-sensitive disease.

Marcia S. Brose, MD, PhD, discusses 2 patient cases of differentiated thyroid cancer (DTC) and explains the DTC treatment landscape.

Expert oncologist Michael Birrer, MD, PhD, reviews the case of a 70-year-old woman with advanced endometrial carcinoma and considers her ideal treatment pathway.

Kevin Kalinsky, MD, MS, provides guidance on treating a patient with HR-positive breast cancer with a CDK4/6 inhibitor, and recommends management strategies for patients who develop relapsed disease.

Chirag A. Shah, MD, discusses the management of an ovarian cancer case and highlights potential treatment options and importance of use of maintenance therapy.

Dan Petrylak, MD, discusses 2 case studies that focus on metastatic castration-sensitive prostate cancer, with emphasis on the use of abiraterone to treat the disease.

Expert oncologist Bobby Liaw, MD, reviews a case of metastatic castration-sensitive prostate cancer and reflects on the optimal treatment approach and management.

John Allan, MD, reviews the diagnosis and treatment of a 67-year-old man with chronic lymphocytic leukemia while highlighting potential treatment options.

Doctor Daniel Greenwald reflects on decisions to treat a woman with newly diagnosed follicular lymphoma with obinutuzumab-based immunochemotherapy and maintenance therapy.

City of Hope’s Dr Afsaneh Barzi reacts to how an elderly man with metastatic cholangiocarcinoma was treated through multiple lines of therapy and provides recommendations on the appropriate management of the disease in similar scenarios.

Expert oncologist Milind Javle, MD, reflects on the optimal diagnosis and management of metastatic cholangiocarcinoma in the context of a hypothetical patient case.

Matthew R. Smith, MD, PhD reviews treatment options and management of patients with metastatic castration-resistant prostate cancer (mCRPC).