April 29th 2024
Lucia Masarova, MD, PhD, elaborated on the latest updates across myeloproliferative neoplasms, focusing on significant studies and emerging therapeutic approaches.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Hematology Experts Review Impactful Data from 2019 ASH Annual Meeting
December 13th 2019Following the 2019 ASH Annual Meeting, Targeted Oncology spoke with experts from various specialties in hematology. The experts highlighted some of the top abstracts from the meeting that will impact the way multiple myeloma, leukemias, MPNs, and lymphomas are treated.
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BET Inhibitor Combination Induces Spleen and Symptom Responses in Myelofibrosis
December 11th 2019CPI-0610, a selective and potent oral bromodomain and extra-terminal domain inhibitor, induced spleen and symptom responses as early as 12 weeks in combination with the JAK inhibitor ruxolitinib in patients with JAK inhibitor-naïve myelofibrosis, according to the preliminary findings from the phase II MANIFEST trial presented at the 2019 ASH Annual Meeting.
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Navitoclax Shows Activity in Ruxolitinib-Resistant Patients With Myelofibrosis
December 10th 2019Patients with primary or secondary myelofibrosis who developed resistance to ruxolitinib in the frontline setting, showed clinically meaningful spleen responses and improvements in symptoms with the addition of navitoclax to ruxolitinib, according to findings from a phase II study presented at the 2019 ASH Annual Meeting.
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Phase III Study of Momelotinib Launched to Evaluate Efficacy in Patients With Myelofibrosis
December 9th 2019The new phase III MOMENTUM clinical trial, which is evaluating the efficacy of momelotinib, a JAK1, JAK2 and ACVR1 inhibitor, versus active comparator danazol in patients with symptomatic and anemic myelofibrosis, was recently launched globally, according to a press release from Sierra Oncology.
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Preclinical Evidence Generates Buzz Around Novel Off-the-Shelf CAR NK Therapy
December 7th 2019A multi-antigen off-the-shelf chimeric antigen receptor natural killer cell therapy has been included in the ASH annual meeting spotlight due to exciting preclinical evidence. An investigational new drug application was approved in September 2019 for the therapy, labeled as FT596, developed by Fate Therapeutics, and human trials are scheduled to start in the first quater of 2020.
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Phase II Evaluates Vemurafenib/Obinutuzumab in Hairy Cell Leukemia
December 6th 2019Justin Taylor, MD, discusses the rationale for an ongoing phase II trial that is exploring the combination of vemurafenib, a BRAF inhibitor, plus the anti-CD20 monoclonal antibody obinutuzumab in previously untreated patients with classical hairy cell leukemia.
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Mesa Advises Community Oncologists on JAK Inhibitors for Intermediate-Risk Myelofibrosis
November 22nd 2019Ruben Mesa, MD, director of the Mays Cancer Center, UT Health San Antonio MD Anderson Cancer Center, gives advice on using the JAK inhibitors ruxolitinib and fedratinib in the community setting for patients with intermediate-risk myelofibrosis.<br />
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JAK Inhibitors Can Impact Transplant Outcomes in Patients With Myelofibrosis
November 21st 2019In an interview with Targeted Oncology, Davis S. Snyder, MD, discussed the treatment approaches for patients with MF who are candidates for SCT, as well as prognostic scoring systems that can help determine a patient’s likelihood of response to transplant.
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Mesa Explains Risk Assessment For Patients With PMF and How it Affects Treatment
November 5th 2019During a <em>Targeted Oncology </em>live case-based peer perspectives discussion, Ruben A. Mesa, MD, discussed risk assessment and treatment options available based on these assessments for patients with primary myelofibrosis with a group of physicians. Mesa, director of the UT Health San Antonio Cancer Center, explained these treatment options based on a case scenario of a patient with PMF.
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Pemmaraju Reviews a Patient Case With Myelofibrosis Following a Targeted Tweet Chat
October 22nd 2019During a Targeted Oncology tweet chat, Naveen Pemmaraju, MD, and Aaron Gerds, MD, MS, led a discussion on a patient case with myelofibrosis. They reviewed the options from a Twitter poll and how they would approach treatment of this particular patient.
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Fedratinib Re-emerges as FDA-Approved Treatment of Myelofibrosis
October 17th 2019Andrew Kuykendall, MD, discusses the background to the JAK2 inhibitor fedratinib (Inrebic), which was approved by the FDA in August 2019 for the treatment of patients with intermediate-2 or high-risk primary or secondary myelofibrosis, including post–polycythemia vera or post–essential thrombocythemia MF.
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Fedratinib and Ruxolitinib: Advice for Deciding Which Agent to Give and When
October 11th 2019In an interview with <em>Targeted Oncology</em> during the 2019 SOHO Annual Meeting, Andrew Kuykendall, MD discussed similarities and differences between fedratinib and ruxolitinib and offered advice to community oncologists who are using JAK inhibition for treating patients with myelofibrosis.
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Imetelstat Granted Fast Track Designation by the FDA
October 1st 2019The FDA has granted a fast track designation to imetelstat for the treatment of adult patients with relapsed or refractory myelofibrosis who have intermediate-2 or high-risk disease. This designation is inclusive of patients with primary MF or those who developed MF after thrombocythemia or polycythemia vera, according to a press release from Geron Corporation, the developer of the drug.<br />
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Curative Therapies Still Needed for First and Second Line Treatment of MPNs
September 24th 2019In an interview with <em>Targeted Oncology</em>, Srdan Verstovsek, MD, PhD, discussed the treatment of MPNs in the community setting and how the field can improve. He also encouraged community oncologist to incorporate quality-of-life measurements and prognostic scoring systems when treating these patients.<br />
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Considering Fedratinib or Ruxolitinib in the Frontline Setting for Treatment of Myelofibrosis
September 24th 2019Ruben Mesa, MD, discusses his experience with fedratinib since its FDA approval for the treatment of patients with myelofibrosis. The agent is compared across trials with ruxolitinib, which has been approved for several years in this space.
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Expert Discusses Methods for Treating Progression in Myelofibrosis
September 20th 2019In an interview with <em>Targeted Oncology</em>,<em> </em>Prithviraj Bose, MD, reviewed his thoughts on identifying and treating progression in myelofibrosis, which he recently presented on during the 2019 SOHO Annual Meeting.
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More Research and Development on JAK Inhibition May Improve Myelofibrosis Management
September 15th 2019In an interview with <em>Targeted Oncology </em>during the 2019 SOHO Annual Meeting, <mark style="background-color:inherit; color:inherit; font-size:14px">Laura C. Michaelis, MD, </mark>discussed the currently approved JAK inhibitors and the future landscape for myelofibrosis, as well as treatment considerations for graft-versus-host disease.
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Fedratinib Approval Further Validates JAK Inhibition for Myelofibrosis Treatment
September 13th 2019In an interview with <em>Targeted Oncology </em>during the 2019 SOHO Annual Meeting, Ruben Mesa, MD, discussed the JAKARTA and JAKARTA-2 studies and the implications their data have on the field of myelofibrosis.
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Pemmaraju Reviews Potential Combination Regimens With Ruxolitinib for Myelofibrosis
September 13th 2019Naveen Pemmaraju, MD, discussed potential combination regimens with ruxolitinib (Jakafi) being explored to improve outcomes for patients with myelofibrosis at the 2019 SOHO Annual Meeting.
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Patients with Relapsed/Refractory Myelofibrosis Achieve Responses to Single-Agent Tagraxofusp
September 5th 2019In an interview with <em>Targeted Oncology</em>, Naveen Pemmaraju, MD, discussed the results from the phase I/II trial of single-agent tagraxofusp used to treat patients with R/R myelofibrosis and examined novel agents and combination regimens that are being studied to potentially treat this patient population.<br /> <br />
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Ruxolitinib and Buparlisib Combo Considered in Early Myelofibrosis Study
August 26th 2019A dose-finding phase Ib study successfully evaluated a combined regimen of oral ruxolitinib and buparlisib in adult patients with intermediate- or high-risk primary or secondary myelofibrosis for safety and efficacy.
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