October 18th 2024
The FREEDOM2 study demonstrates that fedratinib is an effective second-line treatment for myelofibrosis after ruxolitinib failure or intolerance.
September 30th 2024
September 13th 2024
September 12th 2024
6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Fighting Disparities and Saving Lives: An Exploration of Challenges and Solutions in Cancer Care
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Parsaclisib Added to Ruxolitinib Improves Spleen Size and Symptom Burden in Myelofibrosis
April 11th 2021The addition of parsaclisib to ruxolitinib led to improvement in spleen volume reduction and symptom burden in patients with myelofibrosis who had a suboptimal response on a standard dose of ruxolitinib alone, according to results from a phase 2 study.
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FDA Approval Sought for Pacritinib to Treat Patients with Myelofibrosis and Severe Thrombocytopenia
April 1st 2021A rolling submission of a New Drug Application has been completed for pacritinib which is seeking FDA approval as a treatment for patients with myelofibrosis who have severe thrombocytopenia.
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Givinostat Shows Promise for Long-Term Use in Patients With Polycythemia Vera
March 31st 2021In patients with polycythemia vera, long-term use of the histone deacetylase inhibitor givinostat may be warranted after the agent demonstrated tolerable safety and good efficacy over a 4-year period in an ongoing, multicenter, open-label, single-arm study of patients with a chronic myeloproliferative neoplasm who are positive for a JAK2 V617F mutation.
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Emerging Prognostic Tools for Myelofibrosis Further Refine Disease Status
February 2nd 2021Raajit K. Rampal, MD, PhD, hematologic oncologist, Memorial Sloan Kettering Cancer Center, reviewed the prognostic tools used to find indicators of response to treatment in patients with myelofibrosis, during a Targeted Oncology Case-Based Peer Perspective Roundtable discussion.
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Data Support Momelotinib as a Differentiated Approach to Treating Myelofibrosis
January 22nd 2021JAK inhibitors designed for the treatment of myelofibrosis address the splenic response and constitutional symptoms associated with the disease, but the agents are inherently myelosuppressive and can exacerbate anemia and thrombocytopenia.
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Adding Navitoclax to Ruxolitinib Shows Potential in JAK-Resistant Myelofibrosis
January 19th 2021In an interview with Targeted Oncology, Naveen Pemmaraju, MD, discussed the potential role of an add-back strategy as treatment of patients with myelofibrosis who no longer benefited from prior ruxolitinib.
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Fedratinib Appears Safe for Long-Term Treatment of Intermediate- to High-Risk Myelofibrosis
January 12th 2021Twenty-four or more cycles of fedratinib was well-tolerated in patients with intermediate- or high-risk myelofibrosis treated in either the phase 1/2 TED12015 study or the phase 1 TED12037 study. The long-term safety and tolerability results of fedratinib.
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Improving Patient Outcomes With Ruxolitinib in Advanced Myelofibrosis
December 16th 2020Srdan Verstovsek, MD, PhD, discusses how research and future clinical trials can better determine the benefit of ruxolitinib as treatment of patients with myelofibrosis, which is often measured in improvements in the quality of life and spleen reductions.
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Evaluation of RESPONSE Trials Guides Use of Ruxolitinib in Polycythemia Vera
December 13th 2020During a Targeted Oncology Case Based Peer Perspectives event, Andrew Kuykendall, MD, assistant member, Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, discussed the use of ruxolitinib as treatment of 67-year-old patients with polycythemia vera.
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Luspatercept Demonstrates Efficacy and Tolerable Safety in Patients With MDS/MPN-RS-T
December 7th 2020Luspatercept demonstrated clinical efficacy and a tolerable safety profile in patients with myelodysplastic syndrome/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis who were enrolled in the MEDALIST trial.
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Navitoclax Plus Ruxolitinib Improves Spleen Volume, Symptoms in R/R Myelofibrosis
December 5th 2020Improvements in spleen volume and total symptom score were clinically meaningful with the addition of navitoclax to ruxolitinib in patients with myelofibrosis who no longer benefited from prior ruxolitinib therapy.
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The Role of JAK Inhibitors Continues to Evolve to Improve Outcomes in Myelofibrosis
November 10th 2020In an interview with Targeted Oncology, John O. Mascarenhas, MD, discussed the evolving role of JAK inhibitors for the treatment of patients with myelofibrosis, including new agents under evaluation in randomized studies and potential combination strategies that may also improve outcomes.
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