Skin Cancers

Engineered Cellular Therapies Enter Treatment Landscape of Melanoma

May 04, 2020

In an interview with Targeted Oncology, Bruce L. Levine, PhD, discussed hot topics in the treatment landscape of melanoma, including the development of chimeric antigen receptor T and NK cells.

Combination Regimens Inspire Hope for the Treatment of Melanoma

May 04, 2020

In an interview with Targeted Oncology, Michael A. Davies, MD, PhD, discussed the current treatment landscape of melanoma and the recent advances that have provided a great level of optimism to what has been known to be a very challenging cancer setting.

Positive Treatment Response Reinforced With SGX301 in Cutaneous T-Cell Lymphoma

April 30, 2020

"As anticipated, the data continues to become more compelling with extended SGX301 treatment."

ILLUMINATE-204 Update: Promising Results Reported With Tilsotolimod Plus Ipilimumab in Advanced Melanoma

April 21, 2020

"The clinical benefit suggested for these anti-PD-1 refractory melanoma patients with limited treatment options includes stabilization of disease and even responses, which is creating hope that this combination might be of benefit to patients in the PD-1 refractory setting."

Evaluating Prognosis of Patients With Ocular Melanoma

April 17, 2020

Ragini Kudchadkar, MD, discusses the overall prognosis of patients with ocular melanoma.

Combination Nivolumab and Ipilimumab Shows Efficacy in Advanced Melanoma

April 15, 2020

Georgina V. Long, BSc, PhD, MBBS, FRACP, discusses the design and efficacy of the phase III CheckMate 067 trial for patients with advanced melanoma.

Anti-Cancer Agents as Frontline Treatment of MPNs Lead to Higher Probability of Non-Melanoma Skin Cancers

April 10, 2020

Exposure to ruxolitinib, hydroxyurea, and pipobroman as first-line treatment of Philadelphia-negative myeloproliferative neoplasms alone or in combination with other cytoreductive treatment may increase the probability of patients developing non-melanoma skin cancer, highlighting a need for active dermatological surveillance of these patients, according to findings from the MPN-K study, published in Leukemia.

Novel Intralesional Injection Achieves Complete Histological Clearance in Squamous Cell Carcinoma

April 10, 2020

Treatment with STP705 led to the achievement of complete histological clearance of squamous cell carcinoma in situ in a large proportion of patients, meeting the primary end point of the study, according to an interim analysis of the first 3 cohorts in an ongoing phase II clinical trial in patients with non-melanoma skin cancer announced by Sirnaomics Inc.

FDA Grants Pembrolizumab Priority Review for TMB-High Tumors

April 07, 2020

The FDA has accepted and granted a priority review to a supplemental Biologics License Application for pembrolizumab for the treatment of adult and pediatric patients with unresectable or metastatic solid tumors with tissue tumor mutational burden-high who have progressed following prior treatment and who have no satisfactory alternative treatment options.

Rarity of Uveal Melanoma Challenges Clinical Trial Enrollment

April 04, 2020

In an interview with Targeted Oncology, Richard D. Carvajal, MD, discussed the challenges of conducting clinical trials for the treatment of patients with uveal melanoma, as well as the excitement surrounding 2 potential therapies in this space.