THYROID CANCERS

Andrew Gianoukakis, MD, and Lori Wirth, MD, examine post-hoc analysis data from the phase 3 SELECT trial.

Theodore W. Laetsch, MD, an attending physician with the Cancer Center at Children’s hospital of Philadelphia discusses if there is an increased risk of fractures with larotrectinib in patients with TRK fusion positive thyroid cancer.

Principle study investigator Yuliya Mikheeva, MD, PhD, of Saint-Petersburg State University, discussed the combination of dabrafenib and trametinib for the treatment of anaplastic thyroid cancer in an interview with Targeted Oncology.

Dr Andrew Gianoukakis reviews the study design and key efficacy data of the phase 3 DECISION and SELECT trials.

Andrew Gianoukakis, MD, reviews the NCCN guidelines for the treatment of patients with thyroid cancer.

Dr Andrew Gianoukakis, explores considerations surrounding systemic therapy in patients with RAI-refractory differentiated thyroid cancer.

Marcia Brose, MD and Lori Wirth, MD, discuss molecular testing considerations in patients with radioiodine-refractory DTC.

Experts in the management of thyroid cancer discuss radioactive iodine therapy and the clinical implications of mutational status in RAI- refractory DTC.

The panel of experts share their insights into the definition and clinical presentation of radioiodine-refractory DTC.

Andrew Gianoukakis, MD, reviews the treatment and management options for a 71-year-old woman with RAI- refractory differentiated thyroid cancer.

Experts in thyroid cancer discuss treatment considerations surrounding the use of radioiodine therapy in patients with thyroid cancer.

Andrew Gianoukakis, MD, reviews the case of a 71-year-old woman with RAI-refractory differentiated thyroid cancer and the panel discuss relevant clinical trial data.

A 58-year-old man presented with a solitary nodule on the neck, occasional shortness of breath, and intermittent excessive fatigue. Twelve months after being treated with systemic therapy, symptoms occurred leading the oncologist to discover metastatic disease.

Lori Wirth, MD, discusses the relevance of patient-reported outcomes from the phase 1/2 LIBRETTO-001 study in of selpercatinib in patients with RET-altered medullary thyroid cancer or advanced thyroid cancer.

The FDA has approved cabozantinib for the treatment of patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer that has progressed following prior vascular endothelial growth factor receptor-targeted therapy and who are radioactive iodine-refractory or ineligible.

Can ALK inhibitors have the same impact on other malignancies that harbor ALK rearrangements as is has on non–small cell lung cancer?

Eric Nadler, MD, MPP, led a Case-Based Roundtable discussion on treating a 58-year-old man with thyroid cancer.

Lori Wirth, MD, discusses the future of selpercatinib in RET-altered thyroid cancers. 

In medullary thyroid cancer, older patients are more likely to have more aggressive disease and disease specific mortality.

Twelve months after a male patient with RET-mutant thyroid cancer was no longer asymptomatic, the patient developed symptoms that led the treating physician to discover metastatic disease.

Progression-free survival was significantly prolonged with cabozantinib as treatment of patients with radioiodine-refractory differentiated thyroid cancer in the phase 3 COSMIC-311 clinical trial, showing potential as a new treatment option and leading to the filing of a application for FDA approval.

During a Targeted Oncology Case-Based Roundtable event, Krzysztof Misiukiewicz, MD, discussed the case of a 58-year-old patient with RET-mutated thyroid cancer

A non-randomized, open-label trial of AIC100, an autologous chimeric antigen receptor T-cell agent for the treatment of relapsed/refractory thyroid cancer, is currently recruiting patients at the Weill Cornell Medical College in New York, under the supervision of Koen van Besien, MD, PhD.

During a Targeted Oncology Case-Based Roundtable event, Guilherme Rabinowits, MD, discussed the case of a 58-year-old patient with medullary thyroid cancer.

Erminia Massarelli, MD, PhD, MS, discussed the case of a 58-year-old man with RET-mutant medullary thyroid cancer.

Marie E. Cabanillas, MD, discusses current unmet needs in advanced or metastatic TRK fusion-positive thyroid cancer.

The 2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer expand on discussions about treatment goals and palliative care.

Lori Wirth, MD, discusses unmet needs and future considerations in the management of differentiated thyroid cancer.

Lori Wirth, MD, reviews key efficacy data from the post hoc analysis of the SELECT trial investigating the use of lenvatinib in patients with lung metastases.

An overview of how SELECT trial data affected clinical treatment practice for patients with differentiated thyroid cancer.