HR+/HER2+ Breast Cancer PFS Improved With Abemaciclib
September 29th 2019Patients with advanced hormone receptor–positive, HER2-positive breast cancer had improved progression-free survival when receiving the CDK4/6 inhibitor abemaciclib and endocrine therapy with trastuzumab compared with trastuzumab and chemotherapy, according to findings from the randomized phase II monarcHER trial.<sup>1</sup>
Read More
OS Improvement Seen in Updated Results for Atezolizumab Combo in ES-SCLC
September 29th 2019Frontline atezolizumab plus carboplatin plus etoposide has shown an improvement in overall survival over placebo plus CP/ET in the treatment of patients with extensive-stage small cell lung cancer, according to updated results from the phase III IMpower133 trial.
Read More
OS Improved in Advanced HR+/HER2- Breast Cancer With Ribociclib/Fulvestrant
September 29th 2019Ribociclib with fulvestrant resulted in a clinically significant overall survival benefit compared with placebo in postmenopausal patients with hormone receptor–positive, HER2-negative advanced breast cancer, according to findings from the phase III MONALEESA-3 trial presented at the 2019 ESMO Congress.
Read More
Prolonged pCR Rates Seen in TNBC With Neoadjuvant Pembrolizumab and Chemotherapy
September 29th 2019Patients with early triple-negative breast cancer receiving neoadjuvant treatment with the combination of pembrolizumab and chemotherapy showed extended pathological complete response rates by 13.6 percentage points compared with chemotherapy alone in the phase III KEYNOTE-522 study.
Read More
Phase II Trial Shows Improved Survival in TNBC With Trilaciclib
September 29th 2019A randomized phase II study with patients with metastatic triple-negative breast cancer showed unexpected improved overall survival with the addition of trilaciclib, an investigational CDK4/6 inhibitor, to gemcitabine and cisplatin, even though the combination failed to meet a safety-related primary endpoint.
Read More
Overall Survival May Improve With the Addition of Atezolizumab to T-DM1 for HER2+ Breast Cancer
September 29th 2019The addition of atezolizumab to ado-trastuzumab emtansine improved overall survival in patients with previously treated HER2-positive advanced breast cancer compared with T-DM1 alone, according to a second OS analysis of the phase II KATE2 trial presented at the 2019 ESMO Congress.
Read More
Responses Seen With Enfortumab Vedotin and Pembrolizumab in Advanced Urothelial Cancer
September 29th 2019Enfortumab vedotin in combination with pembrolizumab induced objective responses in close to three-quarters of patients with cisplatin-ineligible locally advanced urothelial cancer, according to the results of a preliminary clinical evaluation.
Read More
Addition of Telaglenastat to Everolimus Extends PFS in Metastatic RCC
September 28th 2019Glutaminase inhibitor telaglenastat added to everolimus extends progression-free survival in patients with heavily pretreated advanced renal cell carcinoma compared with everolimus monotherapy, according to data from the phase II ENTRATA study presented at the 2019 ESMO Congress.
Read More
Olaparib Plus Bevacizumab Extends PFS as Frontline Maintenance in Ovarian Cancer
September 28th 2019The combination of olaparib and bevacizumab as frontline maintenance improved the median progression-free survival by 5.5 months over bevacizumab and placebo in patients with newly diagnosed, advanced ovarian cancer following prior treatment with a platinum-based chemotherapy plus bevacizumab, according to the phase III PAOLA-1 findings presented at the 2019 ESMO Congress.
Read More
Overall Survival Improved With Frontline Osimertinib in EGFR-Positive NSCLC
September 28th 2019Median overall survival was improved by 6.8 months with osimertinib as a first-line treatment for patients with metastatic, <em>EGFR</em>-mutant non–small cell lung cancer compared with erlotinib or gefitinib, despite crossover between arms, according to updated data from the phase III FLAURA study presented at the 2019 ESMO Congress.
Read More
Sacituzumab Govitecan Demonstrates Early Efficacy in Heavily Pretreated Metastatic Urothelial Cancer
September 28th 2019The antibody–drug conjugate sacituzumab govitecan induced objective responses in about 30% of heavily pretreated patients with metastatic urothelial carcinoma in initial results of a phase II trial that were presented at the 2019 ESMO Congress.
Read More
PFS Improved With Frontline Niraparib Maintenance in Ovarian Cancer
September 28th 2019Median progression-free survival was improved by 5.6 months with PARP inhibitor niraparib as first-line treatment for patients with newly diagnosed, advanced ovarian cancer who responded to platinum-based chemotherapy compared with placebo, according to data from the phase III PRIMA study presented at the ESMO Congress 2019 and simultaneously published in the <em>New England Journal of Medicine</em>.
Read More
Combination Cediranib Plus Olaparib Improves PFS in Platinum-Resistant Ovarian Cancer
September 28th 2019Cediranib in combination with olaparib demonstrated an improvement in progression-free survival when used as treatment for patients with platinum-resistant ovarian cancer (PROC). However, the difference in PFS compared with chemotherapy did not achieve statistical significance, according to a randomized trial presented at the 2019 ESMO Congress.
Read More
Combination of Atezolizumab and Bevacizumab Shows Early Efficacy in Unresectable HCC
September 28th 2019Atezolizumab in combination with bevacizumab induced objective responses in patients with unresectable hepatocellular carcinoma, according to results presented at the 2019 ESMO Congress from 2 small clinical trials.
Read More
Pemigatinib Induces Responses in Second-Line FGFR+ Cholangiocarcinoma
September 28th 2019An objective response rate of 35.5% was seen with treatment with pemigatinib, a selective oral inhibitor of FGFR1, 2, and 3, in patients with previously treated, locally advanced or metastatic cholangiocarcinoma with an <em>FGFR2 </em>rearrangement or fusion, according to findings from the phase II FIGHT-202 clinical trial presented at ESMO 2019.
Read More
Survival Benefit Seen With Atezolizumab in High PD-L1 NSCLC
September 28th 2019Single-agent atezolizumab improved overall survival in newly diagnosed patients with wild-type non–small cell lung cancer who had ≥50% expression of PD-L1 on tumor cells or ≥10% expression on tumor-infiltrating immune cells compared with platinum-based chemotherapy, according to the interim survival analysis of the phase III IMpower110 study.
Read More
Trend in OS Benefit Seen With Apalutamide in SPARTAN Trial for Nonmetastatic CRPC
September 27th 2019In the phase III SPARTAN trial, the combination of androgen receptor apalutamide and androgen deprivation therapy led to an overall survival OS benefit compared with placebo/androgen deprivation therapy in patients with nonmetastatic castration-resistant prostate cancer, based on the updated findings presented at the 2019 ESMO Congress.
Read More
OS Benefit Seen in Nonsquamous NSCLC With Triplet Regimen in IMpower130
October 23rd 2018Results from the phase III IMpower130 trial demonstrated a statistically significant improvement in both progression-free survival and overall survival with a triplet regimen of atezolizumab, carboplatin, and nab-paclitaxel compared with chemotherapy alone in patients with previously untreated stage IV nonsquamous non–small cell lung cancer.
Read More
Late-Breaking Research Supports Standard Cisplatin in HPV+ Oropharyngeal Cancer
October 23rd 2018Cisplatin plus radiotherapy improved overall survival compared with cetuximab plus radiotherapy in patients with HPV-positive oropharyngeal cancer, according to late-breaking research from the De-ESCALaTE HPV trial presented at the 2018 ESMO Congress.<sup> </sup>Results from this trial support the use of chemoradiotherapy as the standard of care for treatment in this patient population.
Read More
Entrectinib Induces Responses Across Multiple Tumor Types
October 22nd 2018Among patients with advanced solid tumors associated with <em>NTRK</em> gene fusions, more than half had responses to the small-molecule inhibitor entrectinib, according to an integrated analysis of 3 clinical trials presented at the 2018 ESMO Annual Congress.
Read More
Rucaparib Induces Responses in Nearly Half of Men With BRCA+ mCRPC
October 22nd 2018Among men in the ongoing phase II TRITON2 trial with BRCA1/2 alterations, 51% had a confirmed prostate-specific antigen response to rucaparib (Rubraca), according to preliminary data reported in a poster presentation by Wassim Abida, MD, PhD, and colleagues at the 2018 ESMO Congress.
Read More
Larotrectinib Induces 80% ORR in Advanced NTRK+ Solid Tumors
October 22nd 2018Larotrectinib induced an objective response rate of 80% in patients with advanced solid tumors who harbored <em>NTRK </em>gene fusions, according to results pooled from 3 small trials of the TRK inhibitor. Results were presented during the 2018 ESMO Congress.
Read More
Phase II Results of the GEOMETRY Mono-1 Study in NSCLC
October 21st 2018Juergen Wolf, MD, medical director, Center for Integrated Oncology (CIO) at the University Hospital Cologne, discusses the phase II findings of the GEOMETRY mono-1 study in patients with MET exon 14-mutated advanced non-small cell lung cancer.
Read More
SOLAR-1 Trial Results Demonstrate a Benefit for Genomic Testing in Breast Cancer
October 21st 2018Lead investigator Fabrice André, MD, PhD, said findings from the SOLAR-1 trial are the first to show benefit in a genomic subgroup of patients with breast cancer and could open the door for genomic testing in breast cancer.
Read More
Immunotherapy/TKI Combo Induces Favorable Findings in First-Line RCC
October 21st 2018A combination of an immune checkpoint inhibitor and a VEGF inhibitor, avelumab and axitinib, induced 2-fold higher objective response rates compared with sunitinib in patients with treatment-naïve advanced renal cell carcinoma, regardless of their PD-L1 expression. Progression-free survival was also significantly improved over sunitinib, according to findings from the phase III JAVELIN Renal 101 trial presented at the 2018 ESMO Congress.
Read More
PALOMA-3 Analysis Finds Improved OS in Pretreated HR+/HER2- Breast Cancer
October 21st 2018In results from an analysis of the phase III PALOMA-3 trial, patients with hormone receptor-positive, HER2-negative advanced breast cancer who had progressed or relapsed on prior endocrine therapy achieved a clinically meaningful benefit in overall survival from the combination of palbociclib plus fulvestrant.
Read More