Current Evidence and Treatment Approaches in First-Line Metastatic Triple-Negative Breast Cancer

An expert discusses how recent clinical advancements and biomarker-driven strategies are reshaping first-line treatment decisions in metastatic triple-negative breast cancer (mTNBC), emphasizing the critical need for early, optimized therapy to improve outcomes in this aggressive disease.

An expert discusses how emerging trial data, particularly from ASCENT-04, are reshaping first-line treatment strategies for PD-L1–positive metastatic triple-negative breast cancer (mTNBC) by demonstrating the potential superiority of antibody-drug conjugates (ADCs) combined with immunotherapy over standard chemotherapy regimens.

An expert discusses the evolving role of biomarker testing in first-line metastatic triple-negative breast cancer (mTNBC), highlighting how PD-L1, BRCA status, and emerging markers such as Trop-2 expression are shaping personalized treatment approaches and guiding the integration of antibody-drug conjugates (ADCs) and immunotherapy.

An expert discusses the importance of timely biomarker testing and emerging challenges in treatment sequencing for metastatic triple-negative breast cancer (mTNBC), as first-line use of antibody-drug conjugates (ADCs) raises concerns about cross-resistance and the need for strategic postprogression planning.

An expert discusses the importance of managing adverse effects of antibody-drug conjugates (ADCs) in metastatic triple-negative breast cancer (mTNBC), highlighting strategies such as prophylactic growth factor support and emerging genetic screening for UGT1A1 polymorphisms to personalize and optimize patient care.

An expert discusses emerging real-world strategies for managing adverse effects of antibody-drug conjugates (ADCs) in metastatic triple-negative breast cancer (mTNBC), emphasizing the importance of patient education about toxicities such as alopecia while highlighting the potential of ADCs to improve progression-free survival and quality of life.

An expert discusses the complexities of sequencing antibody-drug conjugates (ADCs) in metastatic triple-negative breast cancer, emphasizing the need for biomarker-driven treatment personalization and crossover trial designs to optimize early use and improve patient outcomes.