A Phase II Trial Investigating Vemurafenib for the Treatment of Hairy Cell Leukemia
Jae Park, MD, attending physician, Leukemia Service, Memorial Sloan-Kettering Cancer Center, describes the design of a trial analyzing vemurafenib for the treatment of patients with hairy cell leukemia.
Clinical Pearls
Jae Park, MD, attending physician, Leukemia Service, Memorial Sloan-Kettering Cancer Center, describes the design of a trial analyzing vemurafenib for the treatment of patients with hairy cell leukemia.
- This phase II trial has 13 patients enrolled and is still accruing
- Patients in the trial will receive the same dose of vemurafenib that is approved for the treatment of late-stage melanoma
- Following three cycles of therapy, disease response is assessed, and patients can continue on vemurafenib for three additional cycles
IPSS-del(5q) Scoring System Enhances Risk Assessment in MDS With 5q Deletions
December 11th 2024At the 2024 ASH Annual Meeting, findings suggested that the IPSS-del(5q) Scoring System may more effectively identify risks in MDS with isolated 5q deletions compared to standard MDS scoring systems.
Read More
B019 CAR T-Cell Therapy Shows High Efficacy, Safety in Relapsed/Refractory B-ALL
December 11th 2024Updated phase 2 trial data presented at the 2024 ASH Annual Meeting show that the novel bicistronic CD19/CD22-directed CAR T-cell therapy is safe, durable, and highly effective in children with relapsed/refractory B-ALL.
Read More
Novel BTK Degrader BGB-16673 Shows Activity in WM and CLL/SLL
December 10th 2024The novel Bruton tyrosine kinase degrader BGB-16673 shows promise in relapsed/refractory Waldenström macroglobulinemia previously exposed to BTK inhibitors, and in heavily pretreated patients with R/R chronic lymphocytic leukemia/small lymphocytic lymphoma.
Read More
