|Videos|March 25, 2014

Augmenting the Benefit of Hormonal Therapy in Breast Cancer

Debu Tripathy, MD, co-leader, Women's Cancer Program, University of Southern California Norris Comprehensive Cancer Center, discusses augmenting the benefit of hormonal therapy in breast cancer.

Clinical Pearls

Debu Tripathy, MD, co-leader, Women's Cancer Program, University of Southern California Norris Comprehensive Cancer Center, discusses augmenting the benefit of hormonal therapy in breast cancer.

The CDK4/6 inhibitor palbociclib has yielded exciting preliminarily results
In a phase II study, the combination of palbociclib and letrozole tripled PFS compared with letrozole alone (26.1 months versus 7.5 months)
The HDAC inhibitor entinostat plus hormonal therapy was found to improve survival in a phase II study
Src inhibition showed benefit in a trial

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