Combining HDAC Inhibitors With Immunotherapy in Melanoma

Sanjiv S. Agarwala, MD

Sanjiv S. Agarwala, MD, chairman of medical oncology at St. Luke’s University Health Network, discusses the combination of immunotherapy and a histone deacetylase inhibitor in patients with melanoma, as well as other types of cancer.

Sanjiv S. Agarwala, MD, chairman of medical oncology at St. Luke’s University Health Network, discusses the combination of immunotherapy and a histone deacetylase (HDAC) inhibitor in patients with melanoma, as well as other types of cancer.

Agarwala says that HDAC/immunotherapy combinations, such as seen with pembrolizumab (Keytruda) plus entinostat, could have promise in other diseases in addition to melanoma. Entinostat could also be combined with nivolumab (Opdivo) or other PD-1/PD-L1 antibodies, Agarwala says.