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Opinion|Videos|August 14, 2024

Efficacy and Safety of 2L therapies for RS+ patients

Author(s)Abdulraheem Yacoub, MD

Episodes in this series

EP. 1 ESA-Ineligible LR MDS patient with Transfusion-Dependent Anemia

EP. 1 ESA-Ineligible LR MDS patient with Transfusion-Dependent Anemia

EP. 2 Therapy Selection for ESA Ineligible LR-MDS Patients

EP. 2 Therapy Selection for ESA Ineligible LR-MDS Patients

EP. 3 Mechanism of Action: Imetelstat in LR MDS

EP. 3 Mechanism of Action: Imetelstat in LR MDS

EP. 4 Efficacy and Safety of Imetelstat in ESA- ineligible patients

EP. 4 Efficacy and Safety of Imetelstat in ESA- ineligible patients

EP. 5 Adverse Event Profile & Management of Imetelstat

EP. 6 Comparing Telomerase Inhibitors and EMAs in ESA-Ineligible LR MDS

EP. 6 Comparing Telomerase Inhibitors and EMAs in ESA-Ineligible LR MDS

EP. 7 74- year-old man with LRMDS and Transfusion Dependent Anemia

EP. 7 74- year-old man with LRMDS and Transfusion Dependent Anemia

EP. 8 Efficacy and Safety of 2L therapies for RS+ patients

EP. 8 Efficacy and Safety of 2L therapies for RS+ patients

EP. 9 EMA vs Telomerase Inhibitor for RS+ patients after ESA failure

EP. 9 EMA vs Telomerase Inhibitor for RS+ patients after ESA failure

EP. 10 Optimizing Anemia Management and Addressing Unmet Needs in LR MDS

EP. 10 Optimizing Anemia Management and Addressing Unmet Needs in LR MDS

Please discuss the efficacy and safety findings from studies supporting currently available 2L therapies and how they inform your treatment choices for patients who are RS positive:
IMerge (Platzbecker et al. Lancet 2024) (Santini et al. EHA 2024, Abstr. S184)
MEDALIST (Fenaux et al. NEJM 2020) (Santini et al. ASH 2023, Abstr. 915)
Please describe the similarities/differences between the two trials regarding the data related to defining transfusion independence.
Compare/contrast the data from IMerge and MEDALIST for patients based on whether they received (a) 2 to <4 units, (b) 4 to <6, or (c) ≥6 units every 8 weeks

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