ESA-Ineligible LR MDS patient with Transfusion-Dependent Anemia

Clinical Presentation:

74-year-old man diagnosed 6 months ago with LR-MDS with low-moderate anemia (Hb 11.4 g/dL)

Non-del(5q)

No family history of cancer or significant genotoxic agent exposure

Serum EPO – 550m U/L, Ring sideroblast (RS) negative

Hgb: 10.2 g/dL.

WBC and ANC: WNL

IPSS-R: Low

Received 2-3 units of blood every month for 4 months.

Treatment with ESAs is not an option due to his high serum EPO.