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Opinion|Videos|August 14, 2024

ESA-Ineligible LR MDS patient with Transfusion-Dependent Anemia

Author(s)Abdulraheem Yacoub, MD

Episodes in this series

EP. 1 ESA-Ineligible LR MDS patient with Transfusion-Dependent Anemia

EP. 1 ESA-Ineligible LR MDS patient with Transfusion-Dependent Anemia

EP. 2 Therapy Selection for ESA Ineligible LR-MDS Patients

EP. 2 Therapy Selection for ESA Ineligible LR-MDS Patients

EP. 3 Mechanism of Action: Imetelstat in LR MDS

EP. 3 Mechanism of Action: Imetelstat in LR MDS

EP. 4 Efficacy and Safety of Imetelstat in ESA- ineligible patients

EP. 4 Efficacy and Safety of Imetelstat in ESA- ineligible patients

EP. 5 Adverse Event Profile & Management of Imetelstat

EP. 6 Comparing Telomerase Inhibitors and EMAs in ESA-Ineligible LR MDS

EP. 6 Comparing Telomerase Inhibitors and EMAs in ESA-Ineligible LR MDS

EP. 7 74- year-old man with LRMDS and Transfusion Dependent Anemia

EP. 7 74- year-old man with LRMDS and Transfusion Dependent Anemia

EP. 8 Efficacy and Safety of 2L therapies for RS+ patients

EP. 8 Efficacy and Safety of 2L therapies for RS+ patients

EP. 9 EMA vs Telomerase Inhibitor for RS+ patients after ESA failure

EP. 9 EMA vs Telomerase Inhibitor for RS+ patients after ESA failure

EP. 10 Optimizing Anemia Management and Addressing Unmet Needs in LR MDS

EP. 10 Optimizing Anemia Management and Addressing Unmet Needs in LR MDS

Clinical Presentation:

74-year-old man diagnosed 6 months ago with LR-MDS with low-moderate anemia (Hb 11.4 g/dL)

Non-del(5q)

No family history of cancer or significant genotoxic agent exposure

Serum EPO – 550m U/L, Ring sideroblast (RS) negative

Hgb: 10.2 g/dL.

WBC and ANC: WNL

IPSS-R: Low

Received 2-3 units of blood every month for 4 months.

Treatment with ESAs is not an option due to his high serum EPO.

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