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Opinion|Videos|January 20, 2025

Evolving Paradigms, CAR T, and Treatment Selection in Early-Stage R/R MM

Author(s)Amrita Krishnan, MD

The panelist discusses how the treatment landscape for early-stage relapsed/refractory multiple myeloma (R/R MM) has evolved significantly with CAR T-cell therapies (idecabtagene vicleucel, ciltacabtagene autoleucel [ide-cel, cilta-cel]) and novel drug combinations. Treatment selection now considers prior therapies, patient characteristics, and response duration. For third-line chimeric antigen receptor (CAR) T after no prior CAR T use, cilta-cel shows favorable efficacy data with deeper, more durable responses than ide-cel, though both are viable options.

Episodes in this series

1 expert in this video

EP. 1 A 70-Year-Old Man with Early Relapsed/Refractory Multiple Myeloma

1 expert in this video

EP. 2 Evolving Paradigms, CAR T, and Treatment Selection in Early-Stage R/R MM

1 expert in this video

EP. 3 Ide-Cel and KarMMa-3: Exploring the latest CAR T Data for Early R/R MM

1 expert in this video

EP. 4 Real-World (RW) Observations from CAR T in R/R Myeloma

1 expert in this video

EP. 5 Managing R/R Multiple Myeloma: Current Strategies and Future Directions in Community Practice

Video content above is prompted by the following:

How has the treatment landscape evolved for patients with early-stage R/R MM?
How has the evolving paradigm affected your approach to treatment selection and sequencing in early-stage R/R MM?
For patients not previously treated with CAR T in the second line (2L), what choice of CAR T therapy would you consider in the 3L setting?
What factors inform your selection of CAR T beyond the 2L setting in MM?
What lessons have you learned from bridging therapy, and how would you advise on optimal strategies?

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