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Opinion|Videos|January 27, 2025

Ide-Cel and KarMMa-3: Exploring the latest CAR T Data for Early R/R MM

Author(s)Amrita Krishnan, MD

The panelist discusses how the KarMMa-3 trial data demonstrated the superior efficacy of ide-cel vs standard regimens in triple-class exposed R/R MM, with a median progression-free survival of 13.3 vs 4.4 months and an overall response rate of 71% vs 42%. The favorable safety profile and significant survival benefit support ide-cel as a preferred option for third-line and greater treatment, particularly in patients with good performance status who can tolerate bridging therapy.

Episodes in this series

1 expert in this video

EP. 1 A 70-Year-Old Man with Early Relapsed/Refractory Multiple Myeloma

1 expert in this video

EP. 2 Evolving Paradigms, CAR T, and Treatment Selection in Early-Stage R/R MM

1 expert in this video

EP. 3 Ide-Cel and KarMMa-3: Exploring the latest CAR T Data for Early R/R MM

1 expert in this video

EP. 4 Real-World (RW) Observations from CAR T in R/R Myeloma

1 expert in this video

EP. 5 Managing R/R Multiple Myeloma: Current Strategies and Future Directions in Community Practice

Video content above is prompted by the following:

How does the latest data from the KarMMa-3 trial inform your decision to treat with idecabtagene vicleucel (ide-cel) for early R/R MM?
How does the efficacy and safety data impact your selection of CAR T in the 3L setting?

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