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Opinion|Videos|January 3, 2025

Exploring ADC/Antibody Combination Therapies in Development for R/R FL

A panelist discusses how loncastuximab tesirine, an antibody-drug conjugate targeting CD19, shows promise in combination with rituximab for R/R FL based on its complementary mechanism of action targeting CD19-expressing B -cells, demonstrated single-agent activity in early studies, and preliminary evidence suggesting potential synergy with anti-CD20 therapy in this setting.

Episodes in this series

Video content above is prompted by the following:

Next, provide context for combination loncastuximab plus+ rituximab in R/R FL.

  • How can novel combinations that include antibody-drug conjugates (ADCs) impact the landscape?
  • Introduce loncastuximab: target, MOA. What was the rationale for testing loncastuximab plus+ rituximab in R/R FL?
  • Patients with FL patients from pPhase 1 loncastuximab in R/R B-NHL
  • What additional preliminary evidence supports the combination in this setting?

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