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Opinion|Videos|January 3, 2025

Exploring ADC/Antibody Combination Therapies in Development for R/R FL

Author(s)Juan Pablo Alderuccio, MD

A panelist discusses how loncastuximab tesirine, an antibody-drug conjugate targeting CD19, shows promise in combination with rituximab for R/R FL based on its complementary mechanism of action targeting CD19-expressing B -cells, demonstrated single-agent activity in early studies, and preliminary evidence suggesting potential synergy with anti-CD20 therapy in this setting.

Episodes in this series

EP. 1 An Overview of the Current Treatment Landscape for R/R FL

EP. 1 An Overview of the Current Treatment Landscape for R/R FL

EP. 2 Exploring ADC/Antibody Combination Therapies in Development for R/R FL

EP. 2 Exploring ADC/Antibody Combination Therapies in Development for R/R FL

EP. 3 An Investigator-Initiated Study of Loncastuximab Tesirine Plus Rituximab for the Treatment of R/R FL

EP. 3 An Investigator-Initiated Study of Loncastuximab Tesirine Plus Rituximab for the Treatment of R/R FL

EP. 4 Recent Safety and Efficacy Updates from the Investigator Initiated Study of Loncastuximab tesirine + Rituximab for the Treatment of R/R FL

EP. 4 Recent Safety and Efficacy Updates from the Investigator Initiated Study of Loncastuximab tesirine + Rituximab for the Treatment of R/R FL

$EP. 5 Key Considerations for the Evolving Treatment Landscape for Relapsed/Refractory Follicular Lymphoma$

EP. 5 Key Considerations for the Evolving Treatment Landscape for Relapsed/Refractory Follicular Lymphoma

$EP. 6 Future Perspectives on the Relapsed/Refractory Follicular Lymphoma Treatment Landscape$

EP. 6 Future Perspectives on the Relapsed/Refractory Follicular Lymphoma Treatment Landscape

Video content above is prompted by the following:

Next, provide context for combination loncastuximab plus+ rituximab in R/R FL.

How can novel combinations that include antibody-drug conjugates (ADCs) impact the landscape?
Introduce loncastuximab: target, MOA. What was the rationale for testing loncastuximab plus+ rituximab in R/R FL?
Patients with FL patients from pPhase 1 loncastuximab in R/R B-NHL
What additional preliminary evidence supports the combination in this setting?

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