59-Year-Old Man With Relapsed Follicular Lymphoma

Diagnostic Work-Up in Follicular Lymphoma

Treatment Approach in Follicular Lymphoma

Advancements in the Treatment of Follicular Lymphoma

Case: A 59-Year-Old Man With Symptomatic Follicular Lymphoma

A 59-year-old man presented to his physician with a 10-lb weight loss and chronic night sweats for the past couple of months. He complained of intermittent fatigue but is able to maintain his current exercise regimen.

PE: enlarged bilateral axillary lymph nodes; enlarged spleen, palpable

Excisional biopsy showed grade 2 follicular lymphoma; CD20+, CD10+

PET/CT showed widespread lymphadenopathy and a large splenic mass measuring 10 cm

Started on R-CHOP; tolerated induction well

Post-therapy PET showed partial remission

Followed by Rituximab maintenance until evidence of disease progression

Core needle biopsy; performed confirmed persistent follicular lymphoma; no transformation

PET at 12 months showed increased size of splenic mass

Patient started on obinutuzumab + bendamustine

Case Based Peer Perspectives

Follicular Lymphoma

A 59-Year-Old Man With Relapsed Follicular Lymphoma