Petros Grivas, MD, PhD, discusses the challenge with biomarker discovery currently in the treatment landscape of urothelial carcinoma.
Petros Grivas, MD, PhD, physician, Seattle Cancer Care Alliance; associate professor, Department of Medicine, Division of Oncology, and clinical director, Genitourinary Cancers Program, University of Washington School of Medicine; and associate member, Clinical Research Division, Fred Hutchinson Cancer Center, discusses the challenge with biomarker discovery currently in the treatment landscape of urothelial carcinoma.
The current challenge is that there are multiple different biomarkers, different assays, and different scoring algorithms being used in clinical trials, Grivas says. This makes biomarker discovery a great exercise, and we continue to discover more biomarkers. However, the challenge is with biomarker validation.
Grivas says whether to lock down biomarker assays could be prospectively validated to evaluate clinical utility of certain biomarkers. In the future, a feasible reproducible biomarker is needed to be used in prospective studies. The data presented at ESMO provide researchers with more knowledge to move the field forward.
FDA Accepts IND for UGN-103 in Low-Grade Intermediate-Risk NMIBC
April 15th 2024An investigational new drug application for UGN-103 was accepted by the FDA. A phase 3 study to assess the safety and efficacy of the agent in low-grade intermediate-risk non-muscle invasive bladder cancer is anticipated.
Read More
PTCy Offers New Hope for Mismatched Stem Cell Transplants in Leukemia, MDS
April 13th 2024Jeff Auletta, MD, discussed how PTCy-based graft-vs-host disease prophylaxis offers a promising approach for expanding access to successful cell transplantation regardless of donor match or patient ethnicity.
Read More