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Opinion|Videos|December 6, 2024

Overview of Bispecifics for R/R Multiple Myeloma

Author(s)Binod Dhakal, MD, MS

Panelist discusses how the RRMM treatment landscape has evolved significantly, with BiTEs emerging as a promising approach. BCMA-targeted BiTEs showed efficacy, while GPRC5D-targeting agents like talquetamab represent promising new options, particularly for patients with BCMA-refractory disease. Key challenges include managing cytokine release syndrome, developing optimal sequencing strategies, addressing drug resistance, and improving accessibility and affordability of novel therapies.

Episodes in this series

1 expert in this video

EP. 1 Patient Profile: A 72-Year-Old Man With RRMM

1 expert in this video

EP. 2 Overview of Bispecifics for R/R Multiple Myeloma

1 expert in this video

EP. 3 MonumenTAL-1: Data Updates of Talquetamab, a GPRC5D-Directed Bispecific Antibody for RRMM

1 expert in this video

EP. 4 Talquetamab Step-Up Dosing Strategies and CRS Monitoring

1 expert in this video

EP. 5 Additional Toxicities in GPRC5D-Directed Bispecifics for RRMM

1 expert in this video

EP. 6 Data and Treatment Considerations for BCMA-Directed Bispecifics in RRMM

1 expert in this video

EP. 7 The Future of Bispecific Therapy for R/R Multiple Myeloma

Video content above is prompted by the following:

How has the treatment landscape evolved in RRMM?
Please elaborate on the role of bispecific T-cell engagers (BiTEs) as well as the development of BiTE targets beyond BCMAs, focusing on GPRC5D.
What are the key unmet needs and challenges in managing patients with RRMM?
What are the main barriers to effective treatment and optimal outcomes for this patient population?

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