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Opinion|Videos|January 23, 2025

Patient Considerations for Front-line Systemic Immunotherapies in uHCC.

James J. Harding, MD, discusses how the initial findings from CheckMate 9DW inform the role of nivolumab plus ipilimumab (NIVO + IPI) in the first-line (1L) treatment landscape for unresectable hepatocellular carcinoma (uHCC), considering factors such as efficacy, safety, and patient characteristics (eg, age) when selecting between first-line systemic immunotherapy (IO) regimens.

Episodes in this series

Video content above is prompted by the following:

  • Given initial findings from CheckMate 9DW, where do you see NIVO + IPI fitting into the 1L treatment landscape for uHCC? Thinking about efficacy vs safety, which factors (eg, age,…) would you consider when selecting between 1L systemic IO regimens?
    • Which patients would be best suited to receiving NIVO + IPI in 1L?

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