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Opinion|Videos|January 9, 2025

Academic Perspectives on Front-line Nivolumab/ Ipilimumab Therapy for uHCC.

James J. Harding, MD, discusses the primary (overall survival [OS]) and secondary end points (overall response rate [ORR], duration of response [DOR]) of the CheckMate 9DW trial, and explores how the inclusion of the lenvatinib (LEN) arm informs the treatment landscape, as well as the safety profiles of first-line systemic immunotherapy in patients with uHCC, focusing on the most significant adverse events seen with nivolumab plus ipilimumab (NIVO + IPI).

Episodes in this series

Video content above is prompted by the following:

  • As you review the trial, discuss the primary (OS) and secondary end points (ORR, DOR). How does inclusion of the LEN arm inform the treatment landscape?
  • Discuss the safety profiles with 1L systemic IO in patients with uHCC.
    • What are the most significant adverse events seen with NIVO + IPI in CheckMate 9DW?

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