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Opinion|Videos|December 22, 2025

Study 309/KEYNOTE-775 5-year Update: Lenvatinib Plus Pembrolizumab in Endometrial Cancer

The KEYNOTE-775 study confirms long-term benefits of Lenvatinib and Pembrolizumab for recurrent endometrial cancer, showing sustained survival rates and efficacy.

Episodes in this series

Ramez N. Eskander, MD, discusses 5-year efficacy outcomes from Study 309/KEYNOTE-775, which explored the combination of lenvatinib and pembrolizumab vs chemotherapy in patients with previously treated advanced endometrial cancer. He emphasizes how the updated data sustain the benefit demonstrated in the primary analysis, despite the fact that cross over was allowed and patients in the control arm had received subsequent systemic anti-cancer therapies.

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