Opinion|Videos|December 22, 2025

Study 309/KEYNOTE-775 5-year Update: Lenvatinib Plus Pembrolizumab in Endometrial Cancer

Author(s)Ramez N. Eskander, MD

The KEYNOTE-775 study confirms long-term benefits of Lenvatinib and Pembrolizumab for recurrent endometrial cancer, showing sustained survival rates and efficacy.

Episodes in this series

1 expert is featured in this series.

EP. 1 Study 309/KEYNOTE-775 5-year Update: Lenvatinib Plus Pembrolizumab in Endometrial Cancer

1 expert is featured in this series.

EP. 2 Safety and Optimal AE Management of Lenvatinib Plus Pembrolizumab in Endometrial Cancer

1 expert is featured in this series.

EP. 3 Molecular Testing and Identifying Appropriate Patients for Lenvatinib Plus Pembrolizumab in Endometrial Cancer

1 expert is featured in this series.

EP. 4 Lenvatinib Plus Pembrolizumab in Endometrial Cancer After Neoadjuvant/Adjuvant Therapy

1 expert is featured in this series.

EP. 5 Real-World Results for Lenvatinib Plus Pembrolizumab in Endometrial Cancer

1 expert is featured in this series.

EP. 6 Using Lenvatinib/Pembrolizumab for Endometrial Cancer in Clinical Practice

Ramez N. Eskander, MD, discusses 5-year efficacy outcomes from Study 309/KEYNOTE-775, which explored the combination of lenvatinib and pembrolizumab vs chemotherapy in patients with previously treated advanced endometrial cancer. He emphasizes how the updated data sustain the benefit demonstrated in the primary analysis, despite the fact that cross over was allowed and patients in the control arm had received subsequent systemic anti-cancer therapies.

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