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Opinion|Videos|December 12, 2025

The Effects of Thrombocytopenia at Diagnosis of MDS

Author(s)Caleb J. Scheckel, DO , Clark Alsfeld, MD

A recent study reveals thrombocytopenia as a significant prognostic factor in low-risk MDS, impacting survival and treatment strategies.

Episodes in this series

EP. 1 Classifying Patients with Low-risk MDS

EP. 1 Classifying Patients with Low-risk MDS

EP. 2 The Role of Red Blood Cell Transfusions in Low-risk MDS

EP. 2 The Role of Red Blood Cell Transfusions in Low-risk MDS

EP. 3 Utilizing ESA’s in Clinical Practice

EP. 3 Utilizing ESA’s in Clinical Practice

EP. 4 Exploring a First-line Treatment for Low-risk MDS

EP. 4 Exploring a First-line Treatment for Low-risk MDS

EP. 5 Optimizing Adherence and AE Management to Luspatercept

EP. 5 Optimizing Adherence and AE Management to Luspatercept

EP. 6 Examining Patients with Low Erythropoietin Levels and Low-risk MDS

EP. 6 Examining Patients with Low Erythropoietin Levels and Low-risk MDS

EP. 7 Imetelstat as a Treatment Option for Low-risk MDS

EP. 7 Imetelstat as a Treatment Option for Low-risk MDS

EP. 8 Unmet Needs in the Management of Patients with Low-risk MDS

EP. 8 Unmet Needs in the Management of Patients with Low-risk MDS

EP. 9 Benefits and Limitations of Long-term Red Blood Cell Transfusions in Patients with Low-risk MDS

EP. 9 Benefits and Limitations of Long-term Red Blood Cell Transfusions in Patients with Low-risk MDS

EP. 10 Clinical Considerations for Erythrocyte-stimulating Agents and Luspatercept

EP. 10 Clinical Considerations for Erythrocyte-stimulating Agents and Luspatercept

EP. 11 The Effects of Thrombocytopenia at Diagnosis of MDS

EP. 11 The Effects of Thrombocytopenia at Diagnosis of MDS

EP. 12 Different Inflammatory Profiles Associated with Low-risk MDS

EP. 12 Different Inflammatory Profiles Associated with Low-risk MDS

EP. 13 Examining a Post-hoc Analysis from the COMMANDS Trial

EP. 13 Examining a Post-hoc Analysis from the COMMANDS Trial

EP. 14 Real-world Outcomes with Luspatercept

EP. 14 Real-world Outcomes with Luspatercept

EP. 15 The Effects of Luspatercept on Hemoglobin Levels

EP. 15 The Effects of Luspatercept on Hemoglobin Levels

EP. 16 Imetelstat as a Second-line Therapy Option in Low-risk MDS

EP. 16 Imetelstat as a Second-line Therapy Option in Low-risk MDS

EP. 17 Exploring Investigational Therapies in Low-risk MDS

EP. 17 Exploring Investigational Therapies in Low-risk MDS

A recent abstract from the 2025 American Society of Hematology (ASH) meeting examined the prognostic impact of thrombocytopenia at diagnosis in Myelodysplastic Syndromes (MDS). The findings align with growing evidence that low platelet counts at diagnosis, or an early subsequent drop, are associated with worse clinical outcomes. For instance, studies show patients with low platelet counts decline in the first 6 months have significantly inferior overall survival and higher risk of progression to acute myeloid leukemia.

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