Giredestrant plus everolimus reduced the risk of progression or death by 44% in the ITT population and 62% in ESR1-mutated disease in phase 3 evERA data published in NEJM.
|Videos|February 7, 2014
The Mechanism of Action of Palbociclib
Author(s)Gunter von Minckwitz, MD, PhD
Gunter von Minckwitz, MD, PhD, Chairman, German Breast Group, Professor of Gynecology, University of Frankfurt, Germany, explains the mechanism of palbociclib, a novel oral selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6
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Gunter von Minckwitz, MD, PhD, Chairman, German Breast Group, Professor of Gynecology, University of Frankfurt, Germany, explains the mechanism of palbociclib, a novel oral selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6.
Clinical Pearls:
- By inhibiting CDK 4 and 6, the agent prevents DNA synthesis by prohibiting progression from G1 to S phase of the cell cycle
- The agent also inhibits phosphorylation of the RB protein
- Palbociclib prohibits cell proliferation
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