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Opinion|Videos|November 1, 2023

The Role of Lymphocyte-Activation Gene 3 (LAG-3) in Metastatic Melanoma

Author(s)Hussein A. Tawbi, MD, PhD

Hussein Tawbi, MD, PhD, explains that LAG-3 is a marker of T-cell exhaustion, and combining LAG-3 inhibitors with PD-1 inhibitors can reverse this exhaustion, enhancing T-cell effectiveness and showing therapeutic benefits in patients with metastatic melanoma.

Episodes in this series

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 1 Case Presentation: A 78-Year-Old Man With Metastatic Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 2 Common Clinical Presentations of Metastatic Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 3 Significance of Biomarker and Genetic Testing in Diagnosing Metastatic Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 4 Available First-Line Systemic Therapy Options for Patients With Metastatic Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 5 The Role of Lymphocyte-Activation Gene 3 (LAG-3) in Metastatic Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 6 Relatlimab/Nivolumab in Metastatic Melanoma: Data From the RELATIVITY-047 Trial

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 7 IO Monotherapy Versus Combination Dual IO Therapy for the First-Line Treatment of Metastatic Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 8 Key Trial Data in the Frontline Treatment of Metastatic Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 9 Managing Adverse Events in Patients With Metastatic Melanoma Receiving First-Line Systemic Therapy

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 10 Case Presentation: A 67-Year-Old Woman With Stage IV Melanoma

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 11 Available First-Line Systemic Therapy Options for Patients With Metastatic Melanoma with a BRAF Mutation

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 12 Nivolumab/Ipilimumab Followed by Dabrafenib/Trametinib in Metastatic Melanoma: Data From the DREAMseq Trial

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 13 Second-Line Treatment Options for Patients With Metastatic or Unresectable Melanoma After Disease Progression

Hussein Tawbi, MD, PhD, smiling at camera.

EP. 14 Clinical Pearls on the Treatment of Metastatic and Unresectable Melanoma

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