Targeted Oncology reviews trending news online for the week of May 8, 2020, including recent updates from studies of COVID-19 and the latest oncology news.
In oncology news, the FDA granted approval to a new treatment for patients with non–small cell lung cancer (NSCLC) who harbor a MET exon 14 skipping mutation and also granted an Orphan Drug Designation to a novel liver-targeted drug for the treatment of patients with hepatocellular carcinoma (HCC). Among other news, data were shared from a phase I/II trial in mesothelioma and from the safety run-in portion of the phase II CANOPY-1 trial in patients with metastatic or advanced NSCLC.
On May 6, 2020, the FDA granted approval to capmatinib (Tabrecta) for the treatment of adult patients with metastatic NSCLC whose tumors have a mutation that leads to MET exon 14 skipping as detected by an FDA-approved test, based on findings from the GEOMETRY mono-I trial.
Dose-limiting toxicities were minimal with the combination of canakinumab plus pembrolizumab (Keytruda), and platinum-based doublet chemotherapy in patients with advanced or metastatic NSCLC who were treated in the safety run-in portion of the phase II CANOPY-1 study. Based on these findings, the 200 mg dose of canakinumab administered subcutaneously every 3 weeks will be used in the next phase of the trial.
MIV-818 was granted an Orphan Drug Designation by the FDA for the treatment of patients with HCC on May 6, 2020. The agent is currently under investigation in a 2-part phase I/IIa study.
In an interview with Targeted Oncology, Lori A. Leslie, MD, discussed the importance of analyzing treatment outcomes in real-world patients with chronic lymphocytic leukemia compared with only reviewing data from clinical trials that do not represent all patients seen in the community setting.
Patients with malignant pleural mesothelioma in a phase I/II trial who received ONCOS-102 added to standard of care pemetrexed- and cisplatin-based chemotherapy in the first-, second-, and later-line settings showed a progression-free survival after 9 months of follow-up that was consistent with previously published data.
Shannon N. Westin, MD, MPH, FACOG, discussed the evolving role of immunotherapy as treatment of patients with endometrial cancer.
Experts in the management of diffuse large B-cell lymphoma discuss the use of novel CD19-antibody mono- and combination therapies to treat relapsed/refractory subpopulations.
A cohort of 10 critically ill patients with coronavirus disease 2019 (COVID-19) received more effective immune response after leronlimab (PRO 140) treatment compared with healthy controls. To disseminate results that can inform the public health in response to COVID-19, CytoDyn announced the publication of their findings in a pre-print manuscript, which has been submitted for publication and is currently under peer review.