Using Platinum Agents in Different Settings of TNBC

Fabrice Andre, MD, PhD

Fabrice André, MD, PhD, professor in the Department of Medical Oncology at the Institut Gustave Roussy in Villejuif, France, addresses questions regarding the use of platinum regimens for patients with triple-negative breast cancer (TNBC). He discusses 2 platinum agents, cisplatin and carboplatin, and when it is recommended that these agents be used. 

Fabrice André, MD, PhD, professor in the Department of Medical Oncology at the Institut Gustave Roussy in Villejuif, France, addresses questions regarding the use of platinum regimens for patients with triple-negative breast cancer (TNBC). He discusses 2 platinum agents, cisplatin and carboplatin, and when it is recommended that these agents be used.

One factor for platinum treatments includes the presence ofBRCAmutations. If a patient presents a germline mutation for eitherBRCA1orBRCA2, a platinum agent such as cisplatin or carboplatin can be used in the frontline setting, according to the results of the TNT trial. However, for individuals that do not show signs of these mutations, platinum agents should not be used in the first-line setting.