EGFR+ Lung Cancer

Based on data from the&nbsp;phase III KEYNOTE-189 trial, the FDA has expanded the approval for&nbsp;pemetrexed injection in combination with pembrolizumab and platinum-based chemotherapy to include the first-line treatment of patients with metastatic nonsquamous non&ndash;small cell lung cancer without <em>EGFR</em> or <em>ALK</em> alterations.

During a presentation at the <em>16th Annual </em>Winter Lung Cancer Conference,&nbsp;Julie R. Brahmer, MD, MSc shed light on some of the immunotherapy treatment options that could be entering the lung cancer pipeline over the next 5 years.

Edward B. Garon, MD,&nbsp;discusses the newer role of immunotherapy in the treatment of patients with unresectable stage III NSCLC with the approval of durvalumab in this setting for patients whose disease has not progressed following concurrent chemoradiation.

Christina S. Baik, MD, MPH,&nbsp;discusses several existing and emerging treatment options for <em>ROS1</em>, <em>BRAF</em>, and <em>NTRK </em>genetic aberrations.

During a presentation at the 16th Annual Winter Lung Conference, Gregory J. Riely, MD, PhD, discusses how oncologists can differentiate between the&nbsp;many EGFR TKIs available for patients with&nbsp;<em>EGFR</em>-mutant non&ndash;small cell lung cancer.

General Cancer

Bristol-Myers Squibb has announced its decision to withdraw a&nbsp;supplemental biologics license application currently with&nbsp;the FDA seeking frontline approval for the combination of nivolumab and ipilimumab for patients with advanced non&ndash;small cell lung cancer with tumor mutational burden &ge;10 mutations per megabase.

Heather A. Wakelee, MD, discusses the use of osimertinib as a frontline treatment option for patients with <em>EGFR</em>-positive lung cancer.

Both overall survival and progression-free survival were improved in patients with <em>EGFR</em>-mutant nonsquamous cell lung cancer who were treated with the combination of atezolizumab, bevacizumab, and chemotherapy compared with bevacizumab plus chemotherapy, according to an exploratory analysis of the IMpower150 study.

Patients who continued receiving osimertinib after their non&ndash;small cell lung cancer had progressed demonstrated a prolonged benefit beyond the initial progression event, according to a retrospective analysis of 118 patients from The University of Texas MD Anderson Cancer Center and the Moffitt Cancer Center and Research Institute.

Michael Gieske, MD, discusses how his community center was able to implement a lung cancer screening program.

A retrospective analysis of survival data from patients with metastatic non&ndash;small cell lung cancer showed that patients who received treatment at academic centers had better survival rates than those treated at community-based centers, and this disparity was more pronounced when patients were stratified by histology.