EGFR+ Lung Cancer

A Chemoimmunotherapeutic Approach to Nondriver NSCLC

<em>Targeted Oncology</em>, a print and digital resource that offers content and expert opinions on precision medicine in oncology, launched its second &ldquo;Expert Perspective: Virtual Tumor Board&rdquo; on Wednesday, September 12. The Virtual Tumor Board is a video-editorial board discussion that features key opinion leaders from a specific oncological field. This episode will focus on non&ndash;small cell lung cancer.

A&nbsp;supplemental biologics license application for pembrolizumab (Keytruda) has been granted a priority review designation by the FDA for the frontline treatment of patients&nbsp;with locally advanced or metastatic nonsquamous or squamous non&ndash;small cell lung cancer with a PD-L1 expression level of &ge;1% and no <em>EGFR</em> or <em>ALK</em> genomic tumor aberrations.

Frontline pembrolizumab (Keytruda) has been approved by the European Commission for&nbsp;use in combination with standard chemotherapy as a treatment for patients with metastatic nonsquamous non&ndash;small cell lung cancer without <em>EGFR</em>&nbsp;or <em>ALK</em> mutations. The approval is&nbsp;based on results from the phase III KEYNOTE-189 trial.

The review period for a supplemental biologics license application seeking the approval of atezolizumab (Tecentriq) for use in combination with bevacizumab (Avastin), carboplatin, and paclitaxel or the first-line treatment of patients with metastatic nonsquamous non&ndash;small cell lung cancer has been extended by the FDA.