May 1st 2024
The combination of pembrolizumab, trastuzumab, and chemotherapy showed significant improvement in overall survival vs placebo in patients with HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
View More
6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
Register Now!
Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
View More
Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
View More
41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
View More
Marshall Details Treatment Options for Patients With GI Cancers in 2 Case Studies
June 21st 2018John Marshall, MD, recently shared the treatment considerations and decisions he makes when treating patients with gastrointestinal (GI) cancers. Marshal, chief of the Division of Hematology/Oncology, director of the Otto J. Ruesch Center for the Cure of GI Cancer, Medstar Georgetown University Hospital, in Washington, DC, explained his treatment decisions based on a case scenario during a <em>Targeted Oncology </em>live case-based peer perspectives presentation.
Read More
Advancing Interest in Immune Checkpoint Blockade for GI Cancers
June 19th 2018Maria Svensson, MD, Lund University, discusses the growing interest in checkpoint inhibitor blockade treatments for gastrointestinal cancers. In the past, there have been promising results with this treatment in metastatic disease.
Watch
MSK Announces New Chief of Gastrointestinal Medical Oncology
June 14th 2018Yelena Y. Janjigian, MD, has been appointed chief of the Gastrointestinal Medical Oncology Service in the Division of Solid Tumor Oncology, Department of Medicine at Memorial Sloan Kettering Cancer Center in New York. She will succeed Leonard Saltz, MD, who had held this position for 5 years. Saltz will assume the position of executive director for clincal value and sustainability.
Read More
Lenvatinib/Pembrolizumab Combo Shows Early Promising Activity in Unresectable HCC
June 13th 2018The combination of the VEGFR/FGFR inhibitor lenvatinib and the PD-1 inhibitor pembrolizumab induced a confirmed overall response rate of 26.9% (95% CI, 11.6%-47.8%) in patients with unresectable hepatocellular carcinoma, according to results from a 2-part, phase Ib trial.
Read More
Oncology Experts Reflect on Key Takeaways from Data Presented at ASCO Annual Meeting
June 7th 2018The 2018 ASCO Annual Meeting was a great success, with over 40,000 people in attendance and over 5000 abstracts presented from June 1-5 in Chicago, Illinois. Data from several phase III trials in lung cancer were presented, with especially significant results in non–small cell lung cancer. Other big areas during this year’s meeting included breast, gastrointestinal, genitourinary, and hematologic cancers.
Read More
Patients With Advanced HCC See Extended Survival With Ramucirumab
June 7th 2018In results from the phase III REACH-2 trial, ramucirumab reduced the risk of death by 29% versus placebo as a second-line treatment for patients with advanced hepatocellular carcinoma. Results from the study were presented during the 2018 ASCO Annual Meeting.
Read More
Over-the-Counter Chemoprevention Strategy Reduces Risk for Esophageal Cancer
June 5th 2018According to updated findings from the phase III ASPECT trial presented at the 2018 ASCO Annual Meeting, a combination of 2 over-the-counter drugs can reduce the risk for high-grade dysplasia or esophageal cancer in patients with Barrett’s esophagus if taken for at least 7 years. These results also demonstrated that high-dose esomeprazole in combination with a low-dose aspirin was associated with delaying all-cause mortality.
Read More
Potential Role for Neoadjuvant Therapy Seen in Pancreatic Cancer
June 5th 2018According to preliminary findings from the phase III PREOPANC-1 trial, preoperative treatment with chemotherapy and radiation improved overall survival for patients with resectable or borderline resectable pancreatic cancer compared to immediate surgery. These data, presented at the 2018 ASCO Annual Meeting, demonstrated the potential role for neoadjuvant treatment in the pancreatic cancer treatment paradigm.
Read More
FDA Extends Review Period for Lenvatinib in Hepatocellular Carcinoma
June 1st 2018The review period for lenvatinib as a first-line treatment for patients with unresectable hepatocellular carcinoma has been extended by the FDA. According to Eisai and Merck, the companies codeveloping the drug, this will allow ample time to review the application.
Read More
Kim Details the Rationale for Regorafenib in GI Cancers
June 1st 2018Richard Kim, MD, recently discussed the treatment considerations and decisions he makes when treating patients with hepatocellular carcinoma. Kim, an associate professor oncology, University of South Florida College of Medicine, and medical oncologist, Gastrointestinal Oncology Department, Moffitt Cancer Center, explained his treatment decisions based on 2 case scenarios during a <em>Targeted Oncology</em> live case-based peer perspectives program.
Read More
FDA Accepts Application for Cabozantinib in Advanced HCC
May 30th 2018A supplemental new drug application seeking the approval of cabozantinib for the treatment of patients with previously-treated advanced hepatocellular carcinoma has been accepted by the FDA, according to a statement from Exelixis, the company developing the agent.
Read More
NCCN Selects Wui-Jin Koh as Senior Vice President and Chief Medical Officer
May 22nd 2018Wui-Jin Koh, MD, has been selected as senior vice president and chief medical officer of the National Comprehensive Cancer Network. This is a newly-designed position to oversee the NCCN Oncology Research Program.
Read More
Wainberg Considers More Aggressive Treatment for Patients With BRAF-Mutant CRC
May 18th 2018Zev A. Wainberg, MD, recently discussed the treatment considerations and decisions he makes when treating patients with colorectal cancer and hepatocellular carcinoma. Wainberg, co-director of the Gastrointestinal Oncology Program, University of California Los Angeles, explained his treatment decisions based on 2 gastrointestinal case scenarios during a <em>Targeted Oncology</em> live case-based peer perspectives program.
Read More
Expert Highlights Updates in Adjuvant Therapy for GI Cancers
May 15th 2018The adjuvant treatment landscape of gastrointestinal cancers has recently undergone a transformation, with significant findings from several clinical trials. These studies, in gastric, biliary, pancreatic, and colon cancer looked particularly at the use of treatment in the adjuvant setting after surgical resection and have ultimately changed the standards of care for these patients.
Read More
Atezolizumab/Cobimetinib Combo Does Not Improve OS in CRC, Phase III Results Show
May 11th 2018According to topline findings from the phase III IMblaze370 study, treatment with the combination of the PD-L1 inhibitor atezolizumab and the MEK inhibitor cobimetinib failed to improve overall survival versus regorafenib in patients with locally advanced or metastatic colorectal cancer who were previously treated.
Read More
Additional Analyses Show Consistent Benefit With Regorafenib in HCC
May 9th 2018According to additional analyses from the phase III RESORCE trial published in the<em> Journal of Hepatology, s</em>econd-line regorafenib continued to show antitumor activity regardless of prior dose or time to progression on frontline sorafenib (Nexavar) for patients with unresectable advanced hepatocellular carcinoma.
Read More