May 1st 2024
The combination of pembrolizumab, trastuzumab, and chemotherapy showed significant improvement in overall survival vs placebo in patients with HER2-positive advanced gastric or gastroesophageal junction adenocarcinoma.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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41st Annual CFS®: Innovative Cancer Therapy for Tomorrow
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Nut Consumption Associated With Improved Survival in Colon Cancer, Study Finds
March 6th 2018According to results from the CALGB 8903 study published in the <em>Journal of Clinical Oncology, </em>there is an association between total nut intake and improved outcomes in patients with stage III colon cancer. Results of the study showed patients who ate at least 2 servings of nuts per week had superior disease-free survival and overall survival.
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Pamrevlumab Granted Fast Track Designation by FDA for Locally Advanced Pancreatic Cancer
March 2nd 2018The FDA has granted a Fast Track designation to pamrevlumab for the treatment of patients with locally advanced, unresectable pancreatic cancer, according to FibroGen, the manufacturer of the first-in-class anti-CTGF antibody.
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Published Data Supports Lenvatinib as Potential New HCC Treatment Option as FDA Weighs Approval
February 27th 2018According to findings from the phase III REFLECT trial now published online in the <em>Lancet,</em><sup> </sup>lenvatinib improved progression-free survival and was noninferior for overall survival compared with sorafenib for the frontline treatment of patients with unresectable hepatocellular carcinoma.
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Louis Weiner to Join John Theurer Cancer Center Advisory Board
February 26th 2018Hackensack Meridian <em>Health</em> John Theurer Cancer Center at Hackensack University Medical Center has appointed Louis M. Weiner, MD, to its advisory board. Weiner is the director of the Georgetown Lombardi Cancer Center and director of the MedStar Georgetown Cancer Institute.
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Overman Discusses Remaining Questions Following Nivolumab Results in MSI-H/dMMR mCRC
February 12th 2018Updated findings of the CheckMate-142 study presented by Michael J. Overman, MD, at the 2018 Gastrointestinal Cancers Symposium continued to support the use of nivolumab alone or in combination with ipilimumab for previously treated patients with DNA mismatch repair-deficient/microsatellite instability-high metastatic colorectal cancer.
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Congratulations, Paul Oberstein, New Director of GI Medical Oncology at Perlmutter Cancer Center
February 9th 2018NYU Langone Health’s Perlmutter Cancer Center has announced that Paul E. Oberstein, MD, a nationally renowned clinician-scientist, will serve as director of Gastrointestinal (GI) Medical Oncology and assistant director of its recently established Pancreatic Cancer Center.
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Lutathera Receives FDA Approval for Treatment of GEP-NETs
January 26th 2018Based on results of the phase III NETTER-1 trial, lutathera (lutetium [177Lu] oxodotreotide) has been approved by the FDA for the treatment of patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors.
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Clinical Benefit of Entrectinib for Patients With Metastatic Pancreatic Cancer
January 26th 2018Michael Pishvaian, MD, PhD, director, Phase I Clinical Program, co-director of the Ruesch Center Pancreatic Cancer Program Medical Oncology, Otto J. Ruesch Center for the Cure of Gastrointestinal Cancer, Georgetown University Lombardi Comprehensive Cancer Center, discusses the results of a study investigating entrectinib in patients with metastatic pancreatic cancer who harbor <em>NTRK</em> and <em>ROS1</em> fusions.
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Pembrolizumab Elicits Promising Activity in HCC Patients Previously Treated With Sorafenib
January 26th 2018In phase II data reported at the 2018 Gastrointestinal Cancers Symposium, treatment with the PD-1 inhibitor pembrolizumab (Keytruda) elicited promising progression-free survival and overall survival results in patients with advanced hepatocellular carcinoma who received previous treatment with sorafenib.
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Ramucirumab/Durvalumab Combo Produces Antitumor Activity in Gastric, GEJ Cancer
January 25th 2018According to findings presented at the 2018 Gastrointestinal Cancers Symposium, the combination of the VEGFR-2 inhibitor ramucirumab (Cyramza) plus the anti–PD-L1 agent durvalumab (Imfinzi) demonstrated antitumor activity in a phase Ia/b study of patients with previously treated advanced gastric or gastroesophageal junction adenocarcinoma.
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Napabucasin/Pembrolizumab Combo Shows Early Signs of Efficacy in mCRC
January 25th 2018According to results reported at the 2018 Gastrointestinal Cancers Symposium, early signs of efficacy were seen with the investigational oral cancer stem cell pathway inhibitor napabucasin (BBI608) combined with the PD-1 inhibitor pembrolizumab (Keytruda) in the first 8 patients enrolled in a multicenter phase I/II trial of patients with metastatic colorectal cancer.
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Sequencing Regorafenib Before Cetuximab Leads to Improved Survival in mCRC
January 24th 2018Superior overall survival was induced with sequencing regorafenib (Stivarga) before cetuximab (Erbitux) compared with the reverse sequence in patients with metastatic colorectal cancer following failure of standard chemotherapy, according to findings from the phase II REVERCE study presented at the 2018 Gastrointestinal Cancers Symposium.
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Nivolumab Produces Durable Responses Alone and With Ipilimumab in MSI-H/dMMR mCRC
January 24th 2018According to 2 analyses presented at the 2018 Gastrointestinal Cancers Symposium, data from the CheckMate-142 study support the use of nivolumab (Opdivo) alone or in combination with ipilimumab (Yervoy) for the treatment of patients with previously treated DNA mismatch repair-deficient/microsatellite instability-high metastatic colorectal cancer.
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Dose Escalating Regorafenib Superior to Standard Dose in CRC, Study Finds
January 23rd 2018According to findings reported during the 2018 Gastrointestinal Cancers Symposium, a weekly dose-escalation strategy of regorafenib (Stivarga) beginning at 80 mg and ending at 160 mg was found to be superior than the previously standard starting dose of 160 mg in patients with metastatic colorectal cancer.
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Cabozantinib Demonstrates OS, PFS Improvement in Advanced HCC
January 23rd 2018According to findings from the phase III CELESTIAL trial released ahead of the 2018 Gastrointestinal Cancers Symposium, cabozantinib (Cabometyx) improved median overall survival by 2.2 months compared with placebo for patients with previously treated advanced hepatocellular carcinoma.
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Nab-Paclitaxel/Gemcitabine Induces Encouraging Responses in Locally Advanced Pancreatic Cancer
January 22nd 2018In patients with newly diagnosed locally advanced pancreatic cancer, induction treatment with nab-paclitaxel (Abraxane) plus gemcitabine induced an overall disease control rate of 77.6%, according to updated findings from the phase II LAPACT trial presented at the 2018 Gastrointestinal Cancers Symposium.
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