HEAD & NECK CANCERS

The American Physical Therapy Association has selected Jean Kozempel, PT, DPT, MS, as the recipient of the 2017 Oncology Section President’s Award. This award honors physical therapists who are proving themselves to be pioneers in the oncology field.

Tipifarnib demonstrated encouraging antitumor activity among patients with <em>HRAS</em>-mutant head and neck squamous cell carcinoma (HNSCC), according to preliminary results of an ongoing phase II proof-of-concept trial (NCT02383927).

Chimeric antigen receptor T-cell therapy with bb2121 demonstrated an objective response rate of 94% in patients with&nbsp;relapsed/refractory multiple myeloma, according to findings from a dose-escalation study. The senior study author, James N. Kochenderfer, MD, presented updated findings from the study during the 2017 ASH Annual Meeting, and commented that 89% of patients had a very good partial response or better, and 56% of patients had a complete remission.&nbsp;<br /> &nbsp;

Head and neck squamous cell cancer is relatively uncommon in the United States compared to other malignancies like non-small&ndash;cell lung cancer and breast cancer. There are about 500,000 cases worldwide every year.

Jennifer Eads, MD, assistant professor of medicine, senior clinical instructor of medicine, University Hospitals Cleveland Medical Center, discusses the difficulties in diagnosing G3 neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs), and the varying treatment approaches for these subsets of patients.

D Neil Hayes, MD, MPH, has been appointed scientific director of the University of Tennessee Health Science Center Institute for Cancer Research and the Van Vleet Endowed Professor in Medical Oncology in the Department of Medicine.

Everett E. Vokes, MD, John E. Ultmann Professor of Medicine and Radiation Oncology, Physician-in-Chief, University of Chicago Medicine and Biological Sciences, Chair, Department of Medicine, discusses the current role of checkpoint inhibitors for the treatment of head and neck cancer during the ESMO 2017 Congress.

Theodoros N. Teknos, MD, has been chosen as the new president and scientific officer of the University Hospitals Seidman Cancer Center. He will be taking over for the current president Nathan Levitan, MD, who will be retiring this year after 9 years in this position.

Lori J. Wirth, MD, discusses the era of precision genotype targeted therapy in advanced thyroid cancer, with a focus on individual targets in subtypes of thyroid cancer.&nbsp;

Supplemental Biologics License Applications (sBLAs) were sent to and accepted by the FDA for a new dosing schedule for nivolumab (Opdivo) across all of the agent&#39;s indications as a montherapy, according to Bristol-Myers Squibb (BMS), the manufacturer of the PD-1 inhibitor.&nbsp;

Robert L. Ferris, MD, PhD, a renowned expert in immunotherapy and a specialist in head and neck cancer, has been named director of the University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center. His new position will start July 1.

Combining the IDO inhibitor epacadostat with nivolumab demonstrated promising signs of activity for patients with squamous cell carcinoma of the head and neck and those with melanoma.

Dhanya K. Nambiar, PhD, Stanford University, discusses a study exploring galectin-1 in combination with radiation and immune checkpoint therapy in head and neck cancers.&nbsp;

Sophie Papa, PhD, MBBS, MRCP, King&rsquo;s College London in the United Kingdom, discusses chimeric antigen receptor (CAR) T-cell therapy for patients with head and neck cancer.

A strong association was found between high PD-L1 expression and local failure following radiotherapy in HPV-negative head and neck squamous cell carcinomas.

Aarti Bhatia, MD, discusses newer single agents and combination treatments being investigated for patients with head and neck cancer.

Benjamin L. Judson, MD, highlights the importance of a multidisciplinary team and shares insight on some of the advancements related to surgery for patients with head and neck cancer.

Lynn Acton, MS, CCC (SLP) discusses&nbsp;the significance of swallowing modalities for patients with head and neck cancer during and after radiation therapy.

The use of low-dose radiotherapy may offer transient benefits; nonetheless the potential for palliative care exists.

Beyond hematologic malignancies, adoptive therapy could potentially&nbsp;be effective in solid tumors, such as head and neck cancer, according to early results of a clinical trial.

Immunotherapy agents have shown great promise for the treatment of patients with head and neck cancer; however, only a small subset of patients reap these benefits. Thus, the question becomes: which patients are more likely to benefit from these therapies, and why?

Dhanya Nambiar, PhD, discusses&nbsp;he role of galectin-1 in the tumor microenvironment, and the potential for targeting this protein in patients with head and neck cancer.

Joseph Ciccolini, PhD, assistant professor in Pharmocokinetics, Aix-Marseille University, discusses how dosing adjustments may be used to increase the efficacy of agents, such as cetuximab (Erbitux) in patients with head and neck cancer.

The IDO1 inhibitor BMS-986205 had &quot;best-in-class&quot; activity as demonstrated by kynurenine reductions and IDO1 inhibition for patients with advanced tumors in a phase I/IIa study.

Tanguy Seiwert, MD, discusses&nbsp;advances and next steps with immunotherapy, as well as the overall challenges and goals for treating patients with head and neck cancer.

Nivolumab (Opdivo) has been recommended for approval by&nbsp;EMA&rsquo;s Committee for Medicinal Products for Human Use for the treatment of patients with squamous cell cancer of the head and neck following progression on platinum-based therapy.

A study presented at the 2017 Cancer Survivorship Symposium revealed a long-term cardiovascular risk associated with administration of levothyroxine.

Shlomo Koyfman, MD, associate staff, radiation oncology, Cleveland Clinic, discusses intensity-modulated radiation therapy (IMRT) and stereotactic body radiotherapy (SBRT) reirradiation for patients with head and neck cancer.

The International Federation of Head and Neck Oncologic Societies recently completed its fourth tour, with 8 experts in the field of head and neck oncology traveling to 8 countries over a month to offer continuing medical education courses on treatment paradigms and surgical techniques in head and neck cancer across the world.

Following the approval of 2 immunotherapy agents, pembrolizumab and nivolumab for the treatment of patients with head and neck cancer over the last 6 months, immunotherapy is making its mark on the treatment paradigm for HNC.