April 1 2020

New Homologous Recombination Deficiency Findings in Pancreatic Cancer Alter Treatment Focus

April 03, 2020

Clinical Articles

PARP inhibitors following platinum-based chemotherapy as well as immunotherapy combinations have shown early signs of efficacy in metastatic pancreatic cancer with homologous recombination deficiency, according to data presented at the 2020 Gastrointestinal Cancers Symposium, held January 23 to 25 in San Francisco, California.

Even as Oncology Care Advances, Novel Coronavirus Threatens Our Most Vulnerable Patients

April 04, 2020

Clinical Articles

The Date is March 11, 2020, and fresh off the heels of the Genitourinary Cancers Symposium, I am supposed to be writing about all the exciting research presented and the hope that lies ahead for novel treatments and approaches for urologic cancers.

Meeting Updates Refine Approaches Toward Renal Cell Carcinoma

April 05, 2020

Clinical Articles

Based on new data pertaining to already approved agents and emerging data for novel therapies in the treatment of kidney cancer, a greater understanding of combating advanced tumors is likely to emerge.

Pembrolizumab Leads to Promising Outcomes in Advanced ASCC

April 06, 2020

Clinical Articles

Pembrolizumab demonstrated positive activity in patients with previously treated advanced anal squamous cell carcinoma, regardless of PD-L1 expression, according to the results of the KEYNOTE-158 trial presented at the 2020 Gastrointestinal Cancers Symposium.

Darolutamide Trial Evaluates Noninferiority to Standard Care in Intermediate-Risk Prostate Cancer

April 06, 2020

Clinical Articles

External Beam Radiation therapy with or without androgen deprivation therapy or surgery are the standards of care for men with intermediate-risk prostate cancer, but the adverse events associated with the treatments, delayed testosterone recovery and prolonged erectile dysfunction, are challenges.

Frontline Enfortumab Vedotin Plus Pembrolizumab Exhibits Activity in Advanced Urothelial Carcinoma

April 09, 2020

Clinical Articles

The updated results of the phase Ib/II EV-103 trial demonstrated that treatment-naïve patients with locally advanced or metastatic urothelial cancer who were ineligible for cisplatin-based chemotherapy showed an objective response rate of 73.3% when these patients were treated with enfortumab vedotin-ejfv in combination with pembrolizumab.

Nintedanib Shows Significant Benefit in PFS, OS in Muscle-Invasive Bladder Cancer

April 09, 2020

Clinical Articles

Investigators found no difference in the primary end point of pathologic complete response between the 2 arms of a trial evaluating gemcitabine and cisplatin plus either nintedanib or placebo in muscle-invasive bladder cancer; however; secondary end points of progression-free survival and overall survival demonstrated significant benefit in patients who got nintedanib.

Combining Immune Checkpoint and Androgen Receptor Inhibitors Yields Positive Responses for mCRPC

April 11, 2020

Clinical Articles

Pembrolizumab plus enzalutamide in castration- resistant prostate cancer that exhibited enzalutamide resistance led to positive antitumor signals and a favorable safety profile, according to results of the phase II KEYNOTE-199 trial presented at the 2020 Genitourinary Cancers Symposium.